(+)-JQ1
编号: 16070105
Cas号: 1268524-70-4
纯度: 98% by HPLC
(+)-JQ1 is a BET potent BET bromodomain Inhibitor. Bromodomain and extra terminal domain (BET) proteins are important epigenetic regulators facilitating the transcription of genes in chromatin areas linked to acetylated histones. JQ1 has antiproliferative activity against many cancers, mainly through inhibition of c-MYC and upregulation of p21. JQ1 suppresses tumor growth through downregulating LDHA in ovarian cancer. JQ1 suppresses growth of pancreatic ductal adenocarcinoma in patient-derived xenograft models. JQ1 disrupts human dendritic cell maturation by inhibiting STAT5
仅供研究使用。 我们不向患者出售。
化学信息
| 名称 | (+)-JQ1 |
|---|---|
| Iupac 化学名称 | tert-butyl (S)-2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate |
| 同义词 | (+)JQ1; Bromodomain Inhibitor |
| 英文同义词 | (+)JQ1; Bromodomain Inhibitor |
| 分子式 | C23H25ClN4O2S |
| 分子量 | 456.99 |
| Smile | ClC1=CC=C(C=C1)C1=N[C@H](C=2N(C3=C1C(=C(S3)C)C)C(=NN2)C)CC(=O)OC(C)(C)C |
| InChiKey | DNVXATUJJDPFDM-KRWDZBQOSA-N |
| InChi | InChI=1S/C23H25ClN4O2S/c1-12-13(2)31-22-19(12)20(15-7-9-16(24)10-8-15)25-17(11-18(29)30-23(4,5)6)21-27-26-14(3)28(21)22/h7-10,17H,11H2,1-6H3/t17-/m0/s1 |
| Cas号 | 1268524-70-4 |
| 相关CAS号 |
订购信息
| 包装 | 价格 | 库存 | 纯度 | 备货期 |
|---|---|---|---|---|
| 大货 | 询价 | 询价 | 询价 |
-JQ1-cas-1268524-70-4.png)