(+)-MK-801 is an uncompetitive antagonist of the N-Methyl-D-aspartate (NMDA) receptor, a glutamate receptor discovered by a team at Merck in 1982. (+)-MK-801 has been shown to bind to and inhibit the serotonin and dopamine transporters as well.
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名称 | (+)-MK801(maleate) |
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Iupac 化学名称 | (5S,10R)-(+)-5-Methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine maleate |
同义词 | Dizocilpine maleate, Dizocilpine |
英文同义词 | Dizocilpine maleate, Dizocilpine |
分子式 | C16H15N.C4H4O4 |
分子量 | 337.37 |
Smile | C[C@]12c3ccccc3C[C@H](N1)c4c2cccc4.C(=C\C(=O)O)\C(=O)O |
InChiKey | QLTXKCWMEZIHBJ-FWHYOZOBSA-N |
InChi | InChI=1S/C16H15N.C4H4O4/c1-16-13-8-4-2-6-11(13)10-15(17-16)12-7-3-5-9-14(12)16;5-3(6)1-2-4(7)8/h2-9,15,17H,10H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1-/t15-,16+;/m0./s1 |
Cas号 | 77086-22-7 |
MDL | MFCD00082466 |
相关CAS号 |
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