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2-MNG

编号: 24129
Cas号: 2101538-28-5
纯度: 98% Min.

 2-MNG is an inhibitor for melanogenesis with an average IC50 of 49.5μM. 2-MNG alone significantly reduced immediate darkening and inhibited new melanin production when compared with vehicle, with higher performance at 1% than at 0.5%. 2-MNG at 0.5% in association with LHA and MSX showed significantly higher performance than 2-MNG 0.5% alone. 2-MNG at 0.5% and 1% showed significantly better performance than 4-n-BR.

仅供研究使用。 我们不向患者出售。

化学信息

名称2-MNG
Iupac 化学名称(2-thioxo-1,2-dihydropyridine-3-carbonyl)glycine
同义词2-MNG; 2 MNG; 2MNG; 2-Mercaptonicotinoyl glycine
英文同义词2-MNG; 2 MNG; 2MNG; 2-Mercaptonicotinoyl glycine
分子式C8H8N2O3S
分子量212.23
SmileO=C(O)CNC(C1=CC=CNC1=S)=O
InChiKeyLJJOEVWTSMQPDV-UHFFFAOYSA-N
InChiInChI=1S/C8H8N2O3S/c11-6(12)4-10-7(13)5-2-1-3-9-8(5)14/h1-3H,4H2,(H,9,14)(H,10,13)(H,11,12)
Cas号2101538-28-5
相关CAS号

订购信息

包装价格库存纯度备货期
大货询价询价询价
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外观性状类白色固体
纯度98% Min.
存储 0-4℃,可保存几天到几周;-20℃,可保存 几个月。
可溶性溶于DMSO等有机溶剂
处理方式
运输条件可以在室温下进行运输。
海关编码
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study

1: Sextius P, Warrick E, Prévot-Guéguiniat A, Lereaux G, Boirre F, Baux L, Hassine SB, Qiu J, Huang X, Xu J, Grégoire S, Ito S, Wakamatsu K, Marat X. 2-Mercaptonicotinoyl glycine, a new potent melanogenesis inhibitor, exhibits a unique mode of action while preserving melanocyte integrity. Pigment Cell Melanoma Res. 2024 Jul;37(4):462-479. doi: 10.1111/pcmr.13168. Epub 2024 Apr 1. PMID: 38560773.


2: Dibdiakova K, Majercikova Z, Galanda T, Richterova R, Kolarovszki B, Racay P, Hatok J. Relationship between the Expression of Matrix Metalloproteinases and Their Tissue Inhibitors in Patients with Brain Tumors. Int J Mol Sci. 2024 Mar 1;25(5):2858. doi: 10.3390/ijms25052858. PMID: 38474106; PMCID: PMC10932124.


3: Muller B, Flament F, Jouni H, Sextius P, Tachon R, Wang Y, Wang H, Qiu H, Qiu J, Amar D, Delaunay C, Jablonski NG, Passeron T. A Bayesian network meta- analysis of 14 molecules inhibiting UV daylight-induced pigmentation. J Eur Acad Dermatol Venereol. 2024 Aug;38(8):1566-1574. doi: 10.1111/jdv.19910. Epub 2024 Mar 3. PMID: 38433524.


4: de Dormael R, Sextius P, Bourokba N, Mainguene E, Tachon R, Gaurav K, Jouni H, Bastien P, Diridollou S. 2-Mercaptonicotinoyl glycine prevents UV-induced skin darkening and delayed tanning in healthy subjects: A randomized controlled clinical study. J Cosmet Dermatol. 2024 May;23(5):1745-1752. doi: 10.1111/jocd.16200. Epub 2024 Feb 19. PMID: 38372022.

化学结构

24129 - 2-MNG | CAS 2101538-28-5

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