3PO is a PFKFB3 (6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase) inhibitor. 3PO reduces glycolytic flux and suppresses glucose uptake. 3PO may be useful agents in combination with other drugs that inhibit cancer cell proliferation. PFKFB3 inhibitors suppress glucose uptake, which in turn causes an increase in autophagy. The addition of selective inhibitors of autophagy to 3PO and its more potent derivatives may prove useful as rational combinations for the treatment of cancer.
仅供研究使用。 我们不向患者出售。
化学信息
名称 | 3PO |
Iupac 化学名称 | 3PO |
同义词 | N/A |
英文同义词 | N/A |
分子式 | C13H10N2O |
分子量 | 210.236 |
Smile | c1cc(cnc1)/C=C/C(=O)c2ccncc2 |
InChiKey | UOWGYMNWMDNSTL-ONEGZZNKSA-N |
InChi | InChI=1S/C13H10N2O/c16-13(12-5-8-14-9-6-12)4-3-11-2-1-7-15-10-11/h1-10H/b4-3+ |
Cas号 | 13309-08-5 |
MDL | MFCD00224002 |
相关CAS号 | |
外观性状 | crystalline solid |
纯度 | 98% |
存储 | 3 years -20ºCpowder |
可溶性 | Soluble in DMSO |
处理方式 | |
运输条件 | Shipped under ambient temperature as non-hazardous chemical. |
海关编码 | |
Targets | |
Mechanism | |
Cell study | |
Animal study | |
Clinical study | |