A2793
A2793 is an inhibitor of TRESK (IC50 value of 6.8 μM for mTRESK). A2793 inhibited TWIK-related acid-sensitive K+ channel (TASK)-1 (100 µM, 53.4% ± 13, 5%, n = 5).
仅供研究使用。 我们不向患者出售。
化学信息
| 名称 | A2793 |
|---|---|
| Iupac 化学名称 | Ethyl 2-[(5-chloroquinolin-8-yl)oxy]acetate |
| 同义词 | A2793; A-2793; A2793; |
| 英文同义词 | A2793; A-2793; A2793; |
| 分子式 | C13H12ClNO3 |
| 分子量 | 265.69 |
| Smile | O=C(OCC)COC1=C2N=CC=CC2=C(Cl)C=C1 |
| InChiKey | JEMXUSHXYOXNFL-UHFFFAOYSA-N |
| InChi | InChI=1S/C13H12ClNO3/c1-2-17-12(16)8-18-11-6-5-10(14)9-4-3-7-15-13(9)11/h3-7H,2,8H2,1H3 |
| Cas号 | 88349-90-0 |
| 相关CAS号 |
订购信息
| 包装 | 价格 | 库存 | 纯度 | 备货期 |
|---|---|---|---|---|
| 大货 | 询价 | 询价 | 询价 |
| 外观性状 | Solid powder |
|---|---|
| 纯度 | 98% Min. |
| 存储 | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| 可溶性 | Soluble in DMSO |
| 处理方式 | |
| 运输条件 | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| 海关编码 |
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
1: Lengyel M, Erdélyi F, Pergel E, Bálint-Polonka Á, Dobolyi A, Bozsaki P, Dux M, Király K, Hegedűs T, Czirják G, Mátyus P, Enyedi P. Chemically Modified Derivatives of the Activator Compound Cloxyquin Exert Inhibitory Effect on TRESK (K2P18.1) Background Potassium Channel. Mol Pharmacol. 2019 Jun;95(6):652-660. doi: 10.1124/mol.118.115626. Epub 2019 Apr 12. PMID: 30979812.
2: Bosman WM, Bronkhorst MW. Een vrouw met een pijnlijke enkel [A woman with a painful ankle]. Ned Tijdschr Geneeskd. 2012;156(4):A2793. Dutch. PMID: 22278033.
3: Oehlmann M, Score AJ, Blow JJ. The role of Cdc6 in ensuring complete genome licensing and S phase checkpoint activation. J Cell Biol. 2004 Apr 26;165(2):181-90. doi: 10.1083/jcb.200311044. Epub 2004 Apr 19. PMID: 15096526; PMCID: PMC2172031.
4: Prokhorova TA, Blow JJ. Sequential MCM/P1 subcomplex assembly is required to form a heterohexamer with replication licensing activity. J Biol Chem. 2000 Jan 28;275(4):2491-8. doi: 10.1074/jbc.275.4.2491. PMID: 10644704; PMCID: PMC3626232.
