ABT-639
编号: 6111011
Cas号: 1235560-28-7
纯度: 98%
ABT-639 is a novel, peripherally acting, selective T-type Ca2+ channel blocker. ABT-639 blocks recombinant human T-type (Cav3.2) Ca2+ channels in a voltage-dependent fashion (IC50 = 2 M) and attenuates LVA currents in rat DRG neurons (IC50 = 8 M).
ABT-639 is significantly less active at other Ca2+ channels (e.g. Cav1.2 and Cav2.2) (IC50 > 30 M). ABT-639 has high oral bioavailability (%F = 73), low protein binding (88.9%) and a low brain:plasma ratio (0.05:1) in rodents.
仅供研究使用。 我们不向患者出售。
化学信息
| 名称 | ABT-639 |
|---|---|
| Iupac 化学名称 | ABT-639 |
| 同义词 | ABT639; ABT 639 |
| 英文同义词 | ABT639; ABT 639 |
| 分子式 | C20H20ClF2N3O3S |
| 分子量 | 455.91 |
| InChiKey | |
| InChi | |
| Cas号 | 1235560-28-7 |
| 相关CAS号 |
订购信息
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| 大货 | 询价 | 询价 | 询价 |
