AC-90179 HCl
AC-90179 is a high selective 5-hydroxytryptamine2A receptor inverse agonist. It is an atypical antipsychotic pharmaceutical. It has been shown to alleviate hallucinogen-induced vasocontriction and possible other harmful physical symptoms.
仅供研究使用。 我们不向患者出售。
化学信息
| 名称 | AC-90179 HCl |
|---|---|
| Iupac 化学名称 | 2-(4-Methoxyphenyl)-n-[(4-methylphenyl)methyl]-n-(1-methylpiperidin-4-yl)acetamide hydrochloride |
| 同义词 | AC-90179; AC 90179; AC90179; AC-90179 HCl; AC-90179 hydrochloride |
| 英文同义词 | AC-90179; AC 90179; AC90179; AC-90179 HCl; AC-90179 hydrochloride |
| 分子式 | C23H31ClN2O2 |
| 分子量 | 402.96 |
| Smile | Cl.COC1=CC=C(C=C1)CC(=O)N(C1CCN(CC1)C)CC1=CC=C(C=C1)C |
| InChiKey | JFSJPTRVYLBFQC-UHFFFAOYSA-N |
| InChi | InChI=1S/C23H30N2O2.ClH/c1-18-4-6-20(7-5-18)17-25(21-12-14-24(2)15-13-21)23(26)16-19-8-10-22(27-3)11-9-19;/h4-11,21H,12-17H2,1-3H3;1H |
| Cas号 | 359878-19-6 |
| 相关CAS号 |
订购信息
| 包装 | 价格 | 库存 | 纯度 | 备货期 |
|---|---|---|---|---|
| 大货 | 询价 | 询价 | 询价 |
| 外观性状 | 类白色至白色固体 |
|---|---|
| 纯度 | 98% Min. |
| 存储 | 短期可在0-4度保存，数天至数月；长期可在-20度保存三年。 |
| 可溶性 | 可溶于DMSO；不溶于水 |
| 处理方式 | |
| 运输条件 | 可在常温下运输 |
| 海关编码 |
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
1: Vanover KE, Harvey SC, Son T, Bradley SR, Kold H, Makhay M, Veinbergs I, Spalding TA, Weiner DM, Andersson CM, Tolf BR, Brann MR, Hacksell U, Davis RE. Pharmacological characterization of AC-90179 [2-(4-methoxyphenyl)-N-(4-methyl-benzyl)-N-(1-methyl-piperidin-4-yl)-acetamide hydrochloride]: a selective serotonin 2A receptor inverse agonist. J Pharmacol Exp Ther. 2004 Sep;310(3):943-51. Epub 2004 Apr 21. PubMed PMID: 15102927.
2: Ruderman MA, Powell SB, Geyer MA. A Kappa Opioid Model of Atypical Altered Consciousness and Psychosis: U50488, DOI, AC90179 Effects on Prepulse Inhibition and Locomotion in Mice. J Young Investig. 2009 Jul 1;19(13):1-7. PubMed PMID: 25346645; PubMed Central PMCID: PMC4208663.
3: Blessing WW, Seaman B. 5-hydroxytryptamine(2A) receptors regulate sympathetic nerves constricting the cutaneous vascular bed in rabbits and rats. Neuroscience. 2003;117(4):939-48. PubMed PMID: 12654345.
4: Weiner DM, Burstein ES, Nash N, Croston GE, Currier EA, Vanover KE, Harvey SC, Donohue E, Hansen HC, Andersson CM, Spalding TA, Gibson DF, Krebs-Thomson K, Powell SB, Geyer MA, Hacksell U, Brann MR. 5-hydroxytryptamine2A receptor inverse agonists as antipsychotics. J Pharmacol Exp Ther. 2001 Oct;299(1):268-76. PubMed PMID: 11561089.
