AER-271
AER-271 is a potent aquaporin-4 (AQP4) inhibitor. AER-271 blocks acute cerebral edema and improves early outcome in a pediatric model of asphyxial cardiac arrest. Treatment with AER-271 ameliorated early cerebral edema measured at 3 h after CA vs vehicle treated rats. This treatment also attenuated early NDS. In contrast to rats treated with vehicle after CA, rats treated with AER-271 did not develop significant neuronal death or neuroinflammation as compared to sham.
仅供研究使用。 我们不向患者出售。
化学信息
| 名称 | AER-271 |
|---|---|
| Iupac 化学名称 | 2-{[3,5-Bis(trifluoromethyl) phenyl]carbamoyl}-4-chlorophenyl dihydrogen phosphate |
| 同义词 | AER-271; AER 271; AER271; |
| 英文同义词 | AER-271; AER 271; AER271; |
| 分子式 | C15H9ClF6NO5P |
| 分子量 | 463.6532 |
| Smile | O=P(O)(OC1=CC=C(Cl)C=C1C(NC2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2)=O)O |
| InChiKey | WSHXPHFIHYXZKC-UHFFFAOYSA-N |
| InChi | InChI=1S/C15H9ClF6NO5P/c16-9-1-2-12(28-29(25,26)27)11(6-9)13(24)23-10-4-7(14(17,18)19)3-8(5-10)15(20,21)22/h1-6H,(H,23,24)(H2,25,26,27) |
| Cas号 | 634913-39-6 |
| 相关CAS号 |
订购信息
| 包装 | 价格 | 库存 | 纯度 | 备货期 |
|---|---|---|---|---|
| 大货 | 询价 | 询价 | 询价 |
| 外观性状 | 固体粉末 |
|---|---|
| 纯度 | 98% Min. |
| 存储 | 短期（几天到几周）为0-4摄氏度，长期（几个月）为-20摄氏度 |
| 可溶性 | 可溶于DMSO |
| 处理方式 | |
| 运输条件 | 作为非危险化学品在环境温度下装运。这种产品在正常运输和海关工作期间可以稳定几周 |
| 海关编码 |
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
1: Farr GW, Hall CH, Farr SM, Wade R, Detzel JM, Adams AG, Buch JM, Beahm DL,
Flask CA, Xu K, LaManna JC, McGuirk PR, Boron WF, Pelletier MF. Functionalized
Phenylbenzamides Inhibit Aquaporin-4 Reducing Cerebral Edema and Improving
Outcome in Two Models of CNS Injury. Neuroscience. 2019 Apr 15;404:484-498. doi:
10.1016/j.neuroscience.2019.01.034. Epub 2019 Feb 7. PubMed PMID: 30738082;
PubMed Central PMCID: PMC6495193.
2: Wallisch JS, Janesko-Feldman K, Alexander H, Jha RM, Farr GW, McGuirk PR,
Kline AE, Jackson TC, Pelletier MF, Clark RSB, Kochanek PM, Manole MD. The
aquaporin-4 inhibitor AER-271 blocks acute cerebral edema and improves early
outcome in a pediatric model of asphyxial cardiac arrest. Pediatr Res. 2019
Mar;85(4):511-517. doi: 10.1038/s41390-018-0215-5. Epub 2018 Oct 26. PubMed PMID:
30367162; PubMed Central PMCID: PMC6397683.
3: Kochanek PM, Bramlett HM, Dixon CE, Dietrich WD, Mondello S, Wang KKW, Hayes
RL, Lafrenaye A, Povlishock JT, Tortella FC, Poloyac SM, Empey P, Shear DA.
Operation Brain Trauma Therapy: 2016 Update. Mil Med. 2018 Mar
1;183(suppl_1):303-312. doi: 10.1093/milmed/usx184. PubMed PMID: 29635589.
