AF-353
编号: 16071021
Cas号: 865305-30-2
纯度: 98% by HPLC
AF-353 is a novel, potent and orally bioavailable P2X3/P2X2/3 receptor antagonist, inhibits human and rat P2X3 (pIC50= 8.0). IC50 value: pIC50 = 8.0 (pIC50, for P2X3) Target: P2X3/P2X2/3 receptor in vitro: AF-353 is a highly potent inhibitor of ,-meATP-evoked intracellular calcium flux in cell lines expressing recombinant rat and human P2X3 and human P2X2/3 channels. AF-353 also blocks human P2X2/3 channel function with marginally reduced potency (pIC50 = 7.3). [1] in vivo: SCI rats has significantly higher frequencies for field potentials and NVC than NL rats. Intravesical ATP increases field potential frequency in control but not SCI rats, while systemic AF-353 significantly reduces this parameter in both groups. AF-353 also reduces the inter-contractile interval in control but not in SCI rats; however, the frequency of NVC in SCI rats was significantly reduced
仅供研究使用。 我们不向患者出售。
化学信息
| 名称 | AF-353 |
|---|---|
| Iupac 化学名称 | 2,4-PyriMidinediaMine, 5-[5-iodo-4-Methoxy-2-(1-Methylethyl)phenoxy]- |
| 同义词 | AF-353 |
| 英文同义词 | AF-353 |
| 分子式 | C14H17IN4O2 |
| 分子量 | 400.21 |
| Smile | IC=1C(=CC(=C(OC=2C(=NC(=NC2)N)N)C1)C(C)C)OC |
| InChiKey | AATPYXMXFBBKFO-UHFFFAOYSA-N |
| InChi | InChI=1S/C14H17IN4O2/c1-7(2)8-4-11(20-3)9(15)5-10(8)21-12-6-18-14(17)19-13(12)16/h4-7H,1-3H3,(H4,16,17,18,19) |
| Cas号 | 865305-30-2 |
| 相关CAS号 |
订购信息
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