AM-580
编号: 16062701
Cas号: 102121-60-8
纯度: 98% by HPLC
AM-580 is a potent RARalpha agonist. AM580 has powerful and selective cyto-differentiating effects on acute promyelocytic leukemia cells. AM580 inhibited the wnt pathway, measured by loss of nuclear beta-catenin, suggesting partial oncogene dependence of therapy. Am580 treatment increased RARbeta and lowered the level of RARgamma, an isotype whose expression we linked with tumor proliferation. Specific activation of a single retinoic acid receptor-alpha (RARalpha), without direct and concurrent activation of RARbeta and gamma, will inhibit mammary tumor oncogenesis in murine models relevant to human cancer.
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化学信息
| 名称 | AM-580 |
|---|---|
| Iupac 化学名称 | 4-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalene-2-carboxamido)benzoic acid |
| 同义词 | AM-580; AM 580 |
| 英文同义词 | AM-580; AM 580 |
| 分子式 | C22H25NO3 |
| 分子量 | 351.446 |
| Smile | CC1(C=2C=CC(=CC2C(CC1)(C)C)C(=O)NC1=CC=C(C(=O)O)C=C1)C |
| InChiKey | SZWKGOZKRMMLAJ-UHFFFAOYSA-N |
| InChi | InChI=1S/C22H25NO3/c1-21(2)11-12-22(3,4)18-13-15(7-10-17(18)21)19(24)23-16-8-5-14(6-9-16)20(25)26/h5-10,13H,11-12H2,1-4H3,(H,23,24)(H,25,26) |
| Cas号 | 102121-60-8 |
| 相关CAS号 |
订购信息
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