ARRY-797(CAS 1036404-17-7) is an oral, selective p38 mitogen-activated protein kinase inhibitor. ARRY-797 is being studied in a Phase 3 trial in patients with lamin A/C-related dilated cardiomyopathy (LMNA-related DCM), a rare, degenerative cardiovascular disease caused by mutations in the LMNA gene and characterized by poor prognosis.
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名称 | ARRY-797 (ARRY-371797) |
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Iupac 化学名称 | 5-(2,4-difluorophenoxy)-N-(2-(dimethylamino)ethyl)-1-isobutyl-1H -indazole-6-carboxamide |
同义词 | ARRY-797;ARRY 797;ARRY-371797;ARRY371797; |
英文同义词 | ARRY-797;ARRY 797;ARRY-371797;ARRY371797; |
分子式 | C22H26F2N4O2 |
分子量 | 416.46 |
Smile | O=C(C1=CC2=C(C=C1OC3=CC=C(F)C=C3F)C=NN2CC(C)C)NCCN(C)C |
InChiKey | IFGWYHGYNVGVRB-UHFFFAOYSA-N |
InChi | InChI=1S/C22H26F2N4O2/c1-14(2)13-28-19-11-17(22(29)25-7-8-27(3)4)21(9-15(19)12-26-28)30-20-6-5-16(23)10-18(20)24/h5-6,9-12,14H,7-8,13H2,1-4H3,(H,25,29) |
Cas号 | 1036404-17-7 |
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