Treatment with this PI3K inhibitor enhanced myelination and axon number in the spinal cord of EAE mice. PI3K contributes to development of autoimmune CNS inflammation and that PI3K blockade may provide a great potential for treating patients with MS.
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名称 | AS-604850 |
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Iupac 化学名称 | (Z)-5-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)methylene)thiazolidine-2,4-dione |
同义词 | AS604850; AS 604850; AS-604850. |
英文同义词 | AS604850; AS 604850; AS-604850. |
分子式 | C11H5F2NO4S |
分子量 | 285.22 |
Smile | FC1(OC2=C(O1)C=CC(=C2)\C=C/2\C(NC(S2)=O)=O)F |
InChiKey | SRLVNYDXMUGOFI-YWEYNIOJSA-N |
InChi | InChI=1S/C11H5F2NO4S/c12-11(13)17-6-2-1-5(3-7(6)18-11)4-8-9(15)14-10(16)19-8/h1-4H,(H,14,15,16)/b8-4- |
Cas号 | 648449-76-7 |
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