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AT-007

编号: 25071
Cas号: 2170729-29-8
纯度: 98% Min.

AT-007 is an orally active central nervous system (CNS) penetrant Aldose Reductase inhibitor for treatment of Galactosemia with an IC50 value of 100 pM

仅供研究使用。 我们不向患者出售。

化学信息

名称AT-007
Iupac 化学名称 2-(4-oxo-3-((5-(trifluoromethyl)benzo[d]thiazol-2-yl)methyl)-3,4-dihydrothieno[3,4-d]pyridazin-1-yl)acetic acid
同义词AT-007; AT 007; AT007; Govorestat
英文同义词AT-007; AT 007; AT007; Govorestat
分子式C17H10F3N3O3S2
分子量425.40
SmileO=C(O)CC(C1=CSC=C12)=NN(CC3=NC4=CC(C(F)(F)F)=CC=C4S3)C2=O
InChiKeyORQGHAJIWGGFJK-UHFFFAOYSA-N
InChiInChI=1S/C17H10F3N3O3S2/c18-17(19,20)8-1-2-13-12(3-8)21-14(28-13)5-23-16(26)10-7-27-6-9(10)11(22-23)4-15(24)25/h1-3,6-7H,4-5H2,(H,24,25)
Cas号2170729-29-8
相关CAS号

订购信息

包装价格库存纯度备货期
大货询价询价询价
Request Bulk Quote Download MSDS 电话 : +86-177 0271 9238   Email : sales@sun-shinechem.com
外观性状类白色固体
纯度98% Min.
存储 0-4℃,可保存几天到几周;-20℃,可保存 几个月。
可溶性溶于DMSO等有机溶剂
处理方式
运输条件可以在室温下进行运输。
海关编码
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study

1: Zhu Y, Lobato AG, Rebelo AP, Canic T, Ortiz-Vega N, Tao X, Syed S, Yanick C,
Saporta M, Shy M, Perfetti R, Shendelman S, Züchner S, Zhai RG. Sorbitol
reduction via govorestat ameliorates synaptic dysfunction and neurodegeneration
in sorbitol dehydrogenase deficiency. JCI Insight. 2023 May 22;8(10):e164954.
doi: 10.1172/jci.insight.164954. PMID: 37014713; PMCID: PMC10322690.

2: Perfetti R, Bailey E, Wang S, Mills R, Mohanlal R, Shendelman S. Safety,
Pharmacokinetics, and Pharmacodynamics of the New Aldose Reductase Inhibitor
Govorestat (AT-007) After a Single and Multiple Doses in Participants in a Phase
1/2 Study. J Clin Pharmacol. 2024 Nov;64(11):1397-1406. doi: 10.1002/jcph.2495.
Epub 2024 Jul 10. PMID: 38988185.

3: Bailey E, Phan H, Ahmad A, Thomas J, Ames EG, Pritchard AB, Quinonez SC, Wang
S, Dayley C, Salt A, Pick C, Durrant A, Johnson S, Nicodemus-Johnson J, Dickson
SP, Perfetti R, Hendrix SB, Shendelman S. Results of the ACTION-Galactosemia
Kids Study to Evaluate the Effects of Govorestat in Pediatric Patients with
Classic Galactosemia. J Clin Pharmacol. 2024 Nov 21. doi: 10.1002/jcph.6170.
Epub ahead of print. PMID: 39569553.

4: Randall JA, Sutter C, Wang S, Bailey E, Raither L, Perfetti R, Shendelman S,
Burbridge C. Qualitative interviews with adults with Classic Galactosemia and
their caregivers: disease burden and challenges with daily living. Orphanet J
Rare Dis. 2022 Mar 28;17(1):138. doi: 10.1186/s13023-022-02287-9. PMID:
35346295; PMCID: PMC8959560.

化学结构

25071 - AT-007 | CAS 2170729-29-8

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