1) Sponsor:AstraZeneca
2) Phase: Phase 1
3)AZD9496 is a novel, oral selective oestrogen receptor down-regulator (SERD),used for patients with oestrogen receptor positive (ER+) breast cancer. The oral pharmacokinetic properties of AZD9496 will also be presented [Abs3650], demonstrating the significant pre-clinical tumour efficacy that supported its advance into clinical trials.
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名称 | AZD9496 |
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Iupac 化学名称 | (E)-3-(3,5-difluoro-4-((1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)phenyl)acrylic acid |
同义词 | AZD 9496;AZD-9496 |
英文同义词 | AZD 9496;AZD-9496 |
分子式 | C25H25F3N2O2 |
分子量 | 442.48 |
Smile | O=C(O)/C=C/C1=CC(F)=C([C@H]2N(CC(C)(F)C)[C@H](C)CC3=C2NC4=C3C=CC=C4)C(F)=C1 |
InChiKey | DFBDRVGWBHBJNR-BBNFHIFMSA-N |
InChi | InChI=1S/C25H25F3N2O2/c1-14-10-17-16-6-4-5-7-20(16)29-23(17)24(30(14)13-25(2,3)28)22-18(26)11-15(12-19(22)27)8-9-21(31)32/h4-9,11-12,14,24,29H,10,13H2,1-3H3,(H,31,32)/b9-8+/t14-,24-/m1/s1 |
Cas号 | 1639042-08-2 |
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