Alvelestat (AZD9688)
编号: 16122854
Cas号: 848141-11-7
纯度: 98%
Avelestat, also known as AZD9668, is a novel, oral inhibitor of neutrophil elastase (NE), an enzyme implicated in the signs, symptoms, and disease progression in NE-driven respiratory diseases such as bronchiectasis and chronic obstructive pulmonary disease via its role in the inflammatory process, mucus overproduction, and lung tissue damage. In cell-based assays, AZD9668 inhibited plasma NE activity in zymosan-stimulated whole blood. AZD9668 has the potential to reduce lung inflammation and the associated structural and functional changes in human diseases.
仅供研究使用。 我们不向患者出售。
化学信息
| 名称 | Alvelestat (AZD9688) |
|---|---|
| Iupac 化学名称 | 6-methyl-5-(1-methyl-1H-pyrazol-5-yl)-N-((5-(methylsulfonyl)pyridin-2-yl)methyl)-2-oxo-1-(3-(trifluoromethyl)phenyl)-1,2-dihydropyridine-3-carboxamide |
| 同义词 | ZD9668; AZD 9668; AZD-9668; MPH966; MPH 966; MPH-966; Alvelestat; |
| 英文同义词 | ZD9668; AZD 9668; AZD-9668; MPH966; MPH 966; MPH-966; Alvelestat; |
| 分子式 | C25H22F3N5O4S |
| 分子量 | 545.53 |
| Smile | O=C(C1=CC(C2=CC=NN2C)=C(C)N(C3=CC=CC(C(F)(F)F)=C3)C1=O)NCC4=NC=C(S(=O)(C)=O)C=C4 |
| InChiKey | QNQZWEGMKJBHEM-UHFFFAOYSA-N |
| InChi | InChI=1S/C25H22F3N5O4S/c1-15-20(22-9-10-31-32(22)2)12-21(23(34)30-13-17-7-8-19(14-29-17)38(3,36)37)24(35)33(15)18-6-4-5-16(11-18)25(26,27)28/h4-12,14H,13H2,1-3H3,(H,30,34) |
| Cas号 | 848141-11-7 |
| 相关CAS号 |
订购信息
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