Avatrombopag, also known as AKR-501, YM477, AS 1670542 or E5501, is a novel orally-active thrombopoietin (TPO) receptor agonist. AKR-501 specifically targeted the TPO receptor and stimulated megakaryocytopoiesis throughout the development and maturation of megakaryocytes just as rhTPO did. AKR-501 may be useful in the treatment of patients with thrombocytopenia.
仅供研究使用。 我们不向患者出售。
化学信息
名称 | Avatrombopag |
Iupac 化学名称 | Avatrombopag |
同义词 | AKR501; AKR 501; AKR-501; YM477; YM-477; YM 477; E5501; AS 1670542; AS1670542; AS-1670542; Avatrombopag |
英文同义词 | AKR501; AKR 501; AKR-501; YM477; YM-477; YM 477; E5501; AS 1670542; AS1670542; AS-1670542; Avatrombopag |
分子式 | C29H34Cl2N6O3S2 |
分子量 | 649.65 |
Smile | c1c(cnc(c1Cl)N2CCC(CC2)C(=O)O)C(=O)Nc3nc(c(s3)N4CCN(CC4)C5CCCCC5)c6cc(cs6)Cl |
InChiKey | OFZJKCQENFPZBH-UHFFFAOYSA-N |
InChi | InChI=1S/C29H34Cl2N6O3S2/c30-20-15-23(41-17-20)24-27(37-12-10-35(11-13-37)21-4-2-1-3-5-21)42-29(33-24)34-26(38)19-14-22(31)25(32-16-19)36-8-6-18(7-9-36)28(39)40/h14-18,21H,1-13H2,(H,39,40)(H,33,34,38) |
Cas号 | 570406-98-3 |
MDL | MFCD18633249 |
相关CAS号 | |
外观性状 | crystalline solid |
纯度 | 98% |
存储 | 3 years -20ºCpowder |
可溶性 | Soluble in DMSO |
处理方式 | |
运输条件 | Shipped under ambient temperature as non-hazardous chemical. |
海关编码 | |
Targets | |
Mechanism | |
Cell study | |
Animal study | |
Clinical study | |