BAM 7 is a Bax activator (EC50 = 3.3 M). BCL-2 family proteins are key regulators of the apoptotic pathway. Antiapoptotic members sequester the BCL-2 homology 3 (BH3) death domains of proapoptotic members such as BAX to maintain cell survival. The antiapoptotic BH3-binding groove has been successfully targeted to reactivate apoptosis in cancer.
仅供研究使用。 我们不向患者出售。
化学信息
名称 | BAM 7 |
Iupac 化学名称 | (E)-4-(2-(2-ethoxyphenyl)hydrazono)-5-methyl-2-(4-phenylthiazol-2-yl)-2,4-dihydro-3H-pyrazol-3-one |
同义词 | BAM 7; BAM-7 |
英文同义词 | BAM 7; BAM-7 |
分子式 | C21H19N5O2S |
分子量 | 405.476 |
Smile | C(C)OC1=C(C=CC=C1)N\N=C/1\C(N(N=C1C)C=1SC=C(N1)C1=CC=CC=C1)=O |
InChiKey | KOCVKGYKBLJEPK-LYBHJNIJSA-N |
InChi | InChI=1S/C21H19N5O2S/c1-3-28-18-12-8-7-11-16(18)23-24-19-14(2)25-26(20(19)27)21-22-17(13-29-21)15-9-5-4-6-10-15/h4-13,23H,3H2,1-2H3/b24-19+ |
Cas号 | 331244-89-4 |
相关CAS号 | |
外观性状 | Solid powder |
纯度 | 98% by HPLC |
存储 | -20 ºC for 3 years |
可溶性 | Soluble in DMSO |
处理方式 | |
运输条件 | Shipped under ambient temperature |
海关编码 | |
Targets | |
Mechanism | |
Cell study | |
Animal study | |
Clinical study | |