BAY-2402234
编号: 2071553
Cas号: 2225819-06-5
纯度: 98% Min.
BAY-2402234 is a potent and selective dihydroorotate dehydrogenase (DHODH) inhibitor for the treatment of myeloid malignancies. BAY 2402234 is a selective low-nanomolar inhibitor of human DHODH enzymatic activity. In vitro, it potently inhibits proliferation of AML cell lines in the sub-nanomolar to low-nanomolar range. BAY 2402234 induces differentiation of AML cell lines also in a sub-nanomolar to low-nanomolar range, demonstrating the anticipated mode of action in cellular mechanistic assays. In vivo, BAY 2402234 exhibits strong in vivo anti-tumor efficacy in monotherapy in several subcutaneous and disseminated AML xenografts as well as AML patient-derived xenograft (PDX) models.
仅供研究使用。 我们不向患者出售。
化学信息
| 名称 | BAY-2402234 |
|---|---|
| Iupac 化学名称 | (S)-N-(2-chloro-6-fluorophenyl)-4-(4-ethyl-3-(hydroxymethyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)-5-fluoro-2-((1,1,1-trifluoropropan-2-yl)oxy)benzamide |
| 同义词 | BAY-2402234; BAY 2402234; BAY2402234; |
| 英文同义词 | BAY-2402234; BAY 2402234; BAY2402234; |
| 分子式 | C21H18ClF5N4O4 |
| 分子量 | 520.841 |
| Smile | FC1=C(NC(C2=CC(F)=C(N3N=C(CO)N(CC)C3=O)C=C2O[C@@H](C)C(F)(F)F)=O)C(Cl)=CC=C1 |
| InChiKey | KNVJMHHAXCPZHF-JTQLQIEISA-N |
| InChi | InChI=1S/C21H18ClF5N4O4/c1-3-30-17(9-32)29-31(20(30)34)15-8-16(35-10(2)21(25,26)27)11(7-14(15)24)19(33)28-18-12(22)5-4-6-13(18)23/h4-8,10,32H,3,9H2,1-2H3,(H,28,33)/t10-/m0/s1 |
| Cas号 | 2225819-06-5 |
| 相关CAS号 |
订购信息
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