BAY1217389
编号: 16060801
Cas号: 1554458-53-5
纯度: 98% by HPLC
BAY1217389 is an orally bioavailable, selective inhibitor of the serine/threonine kinase monopolar spindle 1 (Mps1, TTK), with potential antineoplastic activity. Upon administration, the Mps1 inhibitor BAY 1217389 selectively binds to and inhibits the activity of Mps1. This inactivates the spindle assembly checkpoint (SAC), accelerates mitosis, causes chromosomal misalignment and missegregation, and mitotic checkpoint complex destabilization. This induces cell death in Mps1-overexpressing cancer cells
仅供研究使用。 我们不向患者出售。
化学信息
| 名称 | BAY1217389 |
|---|---|
| Iupac 化学名称 | N-cyclopropyl-4-(6-(2,3-difluoro-4-methoxyphenoxy)-8-((3,3,3-trifluoropropyl)amino)imidazo[1,2-b]pyridazin-3-yl)-2-methylbenzamide |
| 同义词 | BAY1217389; BAY-1217389 |
| 英文同义词 | BAY1217389; BAY-1217389 |
| 分子式 | C27H24F5N5O3 |
| 分子量 | 561.513 |
| Smile | C1(CC1)NC(C1=C(C=C(C=C1)C1=CN=C2N1N=C(C=C2NCCC(F)(F)F)OC2=C(C(=C(C=C2)OC)F)F)C)=O |
| InChiKey | WNEILUNVMHVMPH-UHFFFAOYSA-N |
| InChi | InChI=1S/C27H24F5N5O3/c1-14-11-15(3-6-17(14)26(38)35-16-4-5-16)19-13-34-25-18(33-10-9-27(30,31)32)12-22(36-37(19)25)40-21-8-7-20(39-2)23(28)24(21)29/h3,6-8,11-13,16,33H,4-5,9-10H2,1-2H3,(H,35,38) |
| Cas号 | 1554458-53-5 |
| 相关CAS号 |
订购信息
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