BIIB021, also known as CNF2024, is an orally active, purine-scaffold, small-molecule inhibitor of heat shock protein 90 (HSP90) with potential antineoplastic activity. HSP90 inhibitor CNF2024 specifically blocks active HSP90, inhibiting its chaperone function and promoting the degradation of oncogenic signaling proteins involved in tumor cell proliferation and survival; this may result in the inhibition of cellular proliferation in susceptible tumor cell populations.
仅供研究使用。 我们不向患者出售。
化学信息
名称 | BIIB021 |
Iupac 化学名称 | BIIB021 |
同义词 | BIIB 021; BIIB-021; CNF-2024; CNF 2024; CNF2024 |
英文同义词 | BIIB 021; BIIB-021; CNF-2024; CNF 2024; CNF2024 |
分子式 | C14H15ClN6O |
分子量 | 318.76 |
Smile | Cc1cnc(c(c1OC)C)Cn2cnc3c2nc(nc3Cl)N |
InChiKey | QULDDKSCVCJTPV-UHFFFAOYSA-N |
InChi | InChI=1S/C14H15ClN6O/c1-7-4-17-9(8(2)11(7)22-3)5-21-6-18-10-12(15)19-14(16)20-13(10)21/h4,6H,5H2,1-3H3,(H2,16,19,20) |
Cas号 | 848695-25-0 |
MDL | MFCD15528939 |
相关CAS号 | |
外观性状 | crystalline solid |
纯度 | 98% |
存储 | 3 years -20ºCpowder |
可溶性 | Soluble in DMSO |
处理方式 | |
运输条件 | Shipped under ambient temperature as non-hazardous chemical. |
海关编码 | |
Targets | |
Mechanism | |
Cell study | |
Animal study | |
Clinical study | |