BT44
BT44 is a novel RET agonist for the treatment of experimental neuropathies.
仅供研究使用。 我们不向患者出售。
化学信息
| 名称 | BT44 |
|---|---|
| Iupac 化学名称 | (4-(5-((3,4-Dihydroisoquinolin-2(1H)-yl)sulfonyl)-2-methoxyphenyl)piperazin-1-yl)(4-fluoro-2-(trifluoromethyl)phenyl)methanone |
| 同义词 | BT44; BT-44; BT 44 |
| 英文同义词 | BT44; BT-44; BT 44 |
| 分子式 | C28H27F4N3O4S |
| 分子量 | 577.59 |
| Smile | O=C(N1CCN(C2=CC(S(=O)(N3CC4=C(C=CC=C4)CC3)=O)=CC=C2OC)CC1)C5=CC=C(F)C=C5C(F)(F)F |
| InChiKey | MFQBJWVTKPJNEP-UHFFFAOYSA-N |
| InChi | InChI=1S/C28H27F4N3O4S/c1-39-26-9-7-22(40(37,38)35-11-10-19-4-2-3-5-20(19)18-35)17-25(26)33-12-14-34(15-13-33)27(36)23-8-6-21(29)16-24(23)28(30,31)32/h2-9,16-17H,10-15,18H2,1H3 |
| Cas号 | 924759-42-2 |
| 相关CAS号 |
订购信息
| 包装 | 价格 | 库存 | 纯度 | 备货期 |
|---|---|---|---|---|
| 大货 | 询价 | 询价 | 询价 |
| 外观性状 | Solid powder |
|---|---|
| 纯度 | 98% Min. |
| 存储 | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| 可溶性 | Soluble in DMSO |
| 处理方式 | |
| 运输条件 | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| 海关编码 |
| Targets | |
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| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
1: Sverchinsky DV, Nikotina AD, Komarova EY, Mikhaylova ER, Aksenov ND, Lazarev VF, Mitkevich VA, Suezov R, Druzhilovskiy DS, Poroikov VV, Margulis BA, Guzhova IV. Etoposide-Induced Apoptosis in Cancer Cells Can Be Reinforced by an Uncoupled Link between Hsp70 and Caspase-3. Int J Mol Sci. 2018 Aug 25;19(9):2519. doi: 10.3390/ijms19092519. PMID: 30149619; PMCID: PMC6163214.
2: Viisanen H, Nuotio U, Kambur O, Mahato AK, Jokinen V, Lilius T, Li W, Santos HA, Karelson M, Rauhala P, Kalso E, Sidorova YA. Novel RET agonist for the treatment of experimental neuropathies. Mol Pain. 2020 Jan- Dec;16:1744806920950866. doi: 10.1177/1744806920950866. PMID: 32811276.
3: Burr DH, Rollins D, Lee LH, Pattarini DL, Walz SS, Tian JH, Pace JL, Bourgeois AL, Walker RI. Prevention of disease in ferrets fed an inactivated whole cell Campylobacter jejuni vaccine. Vaccine. 2005 Jul 29;23(34):4315-21. doi: 10.1016/j.vaccine.2005.03.038. PMID: 16005742.
4: Hickey TE, Baqar S, Bourgeois AL, Ewing CP, Guerry P. Campylobacter jejuni- stimulated secretion of interleukin-8 by INT407 cells. Infect Immun. 1999 Jan;67(1):88-93. doi: 10.1128/IAI.67.1.88-93.1999. PMID: 9864200; PMCID: PMC96281.
5: McGavock H. Strategies and tactics for effective prescribing during the foundation year. Br J Hosp Med (Lond). 2005 Aug;66(8):Suppl M3-4. doi: 10.12968/hmed.2005.66.Sup1.18523. PMID: 16097522.
