BYK204165 is a potent and selective poly(ADP-ribose) polymerase (PARP)-1 inhibitor (pIC50 values are 5.38 and 7.35 for PARP-2 and PARP-1 respectively). BYK204165 was found to be 100-fold more selective for PARP-1. BYK204165 might be novel and valuable tool for investigating PARP-1-mediated effects.
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化学信息
名称 | BYK204165 |
Iupac 化学名称 | (4Z)-4-[(1-methylpyrrol-2-yl)methylidene]isoquinoline-1,3-dione |
同义词 | BYK204165; BYK-204165 |
英文同义词 | BYK204165; BYK-204165 |
分子式 | C15H12N2O2 |
分子量 | 252.27 |
Smile | CN1C(=CC=C1)\C=C\1/C(NC(C2=CC=CC=C12)=O)=O |
InChiKey | BTYSIDSTHDDAJW-LCYFTJDESA-N |
InChi | InChI=1S/C15H12N2O2/c1-17-8-4-5-10(17)9-13-11-6-2-3-7-12(11)14(18)16-15(13)19/h2-9H,1H3,(H,16,18,19)/b13-9- |
Cas号 | 1104546-89-5 |
相关CAS号 | |
外观性状 | Solid powder |
纯度 | 98% by HPLC |
存储 | -20 ºC for 3 years |
可溶性 | Soluble in DMSO |
处理方式 | |
运输条件 | Shipped under ambient temperature |
海关编码 | |
Targets | |
Mechanism | |
Cell study | |
Animal study | |
Clinical study | |