Brepocitinib Tosylate
编号: 232252
Cas号: 2140301-96-6
纯度: ≧98.0%
Brepocitinib ( PF-06700841 ) is an orally available, selective inhibitor of non-receptor tyrosine-protein kinase TYK2 (tyrosine kinase 2) and tyrosine-protein kinase JAK1 (Janus kinase 1; JAK1) with potential immunomodulatory and anti-inflammatory activities. Upon oral administration, brepocitinib selectively binds to and inhibits the activation of TYK2 and JAK1, thereby disrupting TYK2 and JAK-1-dependent cytokine signaling. This may reduce inflammatory responses and prevent inflammation-induced damage caused by certain immunological diseases. TYK2 and JAK-1 are members of the Janus kinase family of non-receptor tyrosine kinases and are involved in signaling pathways affecting hematopoiesis, immunity and inflammation.
仅供研究使用。 我们不向患者出售。
化学信息
| 名称 | Brepocitinib Tosylate |
|---|---|
| Iupac 化学名称 | ((S)-2,2-difluorocyclopropyl)(3-(2-((1-methyl-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone 4-methylbenzenesulfonate |
| 同义词 | PF-06700841 Tosylate ; Brepocitinib Tosylate |
| 英文同义词 | PF-06700841 Tosylate ; Brepocitinib Tosylate |
| 分子式 | C25H29F2N7O4S |
| 分子量 | 561.60 |
| Smile | O=C([C@H]1C(F)(F)C1)N2C3CN(C4=NC(NC5=CN(C)N=C5)=NC=C4)CC2CC3.O=S(C6=CC=C(C)C=C6)(O)=O |
| InChiKey | FAKGOYNHHHOTEN-WTMFEIAXSA-N |
| InChi | InChI=1S/C18H21F2N7O.C7H8O3S/c1-25-8-11(7-22-25)23-17-21-5-4-15(24-17)26-9-12-2-3-13(10-26)27(12)16(28)14-6-18(14,19)20;1-6-2-4-7(5-3-6)11(8,9)10/h4-5,7-8,12-14H,2-3,6,9-10H2,1H3,(H,21,23,24);2-5H,1H3,(H,8,9,10)/t12?,13?,14-;/m0./s1 |
| Cas号 | 2140301-96-6 |
| 相关CAS号 | 2140301-96-6 |
订购信息
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| 大货 | 询价 | 询价 | 询价 |
