Bunamidine is a anti-parasitic drug, which was approved by FDA for the treatment of tapeworms in cats and dogs (Scolaban 400 tablets).
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名称 | Bunamidine hydrochloride |
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Iupac 化学名称 | 1-Naphthalenecarboximidamide, N,N-dibutyl-4-(hexyloxy)-, monohydrochloride |
同义词 | Bunamidine hydrochloride; Bunamidine HCl; BW62415; BW-62415; BW 62415; Scolaban |
英文同义词 | Bunamidine hydrochloride; Bunamidine HCl; BW62415; BW-62415; BW 62415; Scolaban |
分子式 | C25H39ClN2O |
分子量 | 419.04 |
Smile | N=C(C1=C2C=CC=CC2=C(OCCCCCC)C=C1)N(CCCC)CCCC.[H]Cl |
InChiKey | PBYJDHRFPFHVKZ-UHFFFAOYSA-N |
InChi | InChI=1S/C25H38N2O.ClH/c1-4-7-10-13-20-28-24-17-16-23(21-14-11-12-15-22(21)24)25(26)27(18-8-5-2)19-9-6-3;/h11-12,14-17,26H,4-10,13,18-20H2,1-3H3;1H |
Cas号 | 1055-55-6 |
相关CAS号 |
包装 | 价格 | 库存 | 纯度 | 备货期 |
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大货 | 询价 | 询价 | 询价 |
外观性状 | 固体粉末 |
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纯度 | 98% Min. |
存储 | 短期(几天到几周)为0-4摄氏度,长期(几个月)为-20摄氏度 |
可溶性 | 溶于DMSO |
处理方式 | |
运输条件 | 作为非危险化学品在环境温度下装运。这种产品在正常运输和海关工作期间可以稳定几周. |
海关编码 |
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Mechanism | |
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Animal study | |
Clinical study |
1: Larionova TK, Kudasheva FKh, Bogoliuk GB, Afanaséva LI. Opredelenie promezhutochnykh produktov sinteza bunamidina gidrokhlorida v vozdukhe rabocheĭ rabocheĭ zony metodom vysokoéffectivnoĭ zhidkostnoĭ khromatografii [Evaluation of intermediate products of bunamidine hydrochloride synthesis in the workplace air by high performance liquid chromatography method]. Gig Sanit. 1993 Oct;(10):70-1. Russian. PMID: 8163245.
2: Cruthers LR, Linkenheimer WH, Maplesden DC. Taeniacidal efficacy of SQ 21,704 in dogs by various types of oral administration and in comparison with niclosamide and bunamidine hydrochloride. Am J Vet Res. 1979 May;40(5):676-8. PMID: 573081.
3: Thakur AS, Prezioso U, Marchevsky N. Echinococcus granulosus: ovicidal activity of praziquantel and bunamidine hydrochloride. Exp Parasitol. 1979 Apr;47(2):131-3. doi: 10.1016/0014-4894(79)90066-3. PMID: 571349.
4: Todd KS Jr, Howland TP, Woerpel RW. Activity of uredofos, niclosamide, bunamidine hydrochloride, and arecoline hydrobromide against Mesocestoides corti in experimentally infected dogs. Am J Vet Res. 1978 Feb;39(2):315-6. PMID: 564650.
5: Gemmell MA. The Styx Field Trial: effect of treatment of the definitive host for tapeworms on larval forms in the intermediate host. Bull World Health Organ. 1978;56(3):433-43. PMID: 308408; PMCID: PMC2395586.
6: Roberson EL. Comparative effects of uredofos, niclosamide, and bunamidine hydrochloride against tapeworm infections in dogs. Am J Vet Res. 1976 Dec;37(12):1483-4. PMID: 1033722.
7: King AB. Bunamidine hydrochloride in dogs. J Am Vet Med Assoc. 1976 Nov 1;169(9):854, 856, 858. PMID: 988006.
8: Williams JF, Keahey KK. Sudden death associated with treatment of three dogs with bunamidine hydrochloride. J Am Vet Med Assoc. 1976 Apr 15;168(8):689-91. PMID: 944173.
9: Trejos A, Szyfres B, Marchevsky N. Comparative value of arecoline hydrobromide and bunamidine hydrochloride for the treatment of Echinococcus granulosus in dogs. Res Vet Sci. 1975 Sep;19(2):212-3. PMID: 1172623.
10: Andersen FL, Loveless RM, Jensen LA. Efficacy of bunamidine hydrochloride against immature and mature stages of Echinococcus granulosus. Am J Vet Res. 1975 May;36(5):673-5. PMID: 1169897.
11: Williams GF, Colli CW, Leid RW, MacArthur R. The effects of bunamidine hydrochloride on the infectivity of taeniid ova. J Parasitol. 1973 Dec;59(6):1141-4. PMID: 4796811.
12: Cook BR. A field trial with bunamidine hydrochloride as an anthelmintic in the eradication of Echinococcus granulosus, Taenia hydatigena and Taenia ovis in New Zealand. N Z Vet J. 1970 Aug;18(8):152-5. doi: 10.1080/00480169.1970.33886. PMID: 5273618.
13: Williams JF, Trejos A. The influence of gelatin capsules upon the activity of bunamidine hydrochloride against Echinococcus granulosus in dogs. Res Vet Sci. 1970 Jul;11(4):392-4. PMID: 5499329.
14: Blood BD, Moya V, Lelijveld JL. Evaluation of selected drugs for the treatment of canine echinococcosis. Bull World Health Organ. 1968;39(1):67-72. PMID: 5303842; PMCID: PMC2554388.
15: Forbes LS. The efficiency of bunamidine hydrochloride against young Echinococcus granulosus infection in dogs. Vet Rec. 1966 Sep 10;79(11):306-7. doi: 10.1136/vr.79.11.306. PMID: 5970728.
16: HATTON CJ. A NEW TAENIACIDE, BUNAMIDINE HYDROCHLORIDE: ITS EFFICIENCY AGAINST TAENIA PISIFORMIS AND DIPYLIDIUM CANINUM IN THE DOG AND HYDATIGERA TAENIAEFORMIS IN THE CAT. Vet Rec. 1965 Apr 10;77:408-11. PMID: 14330224.