CAY10505 is a phosphatidylinositol 3-kinase- inhibitor , was found to significantly improve acetylcholine-induced endothelium dependent relaxation, serum nitrate and (or) nitrite level, glutathione level, and the vascular endothelial lining in hypertensive rats. CAY10505 , may improve hypertension-associated vascular endothelial dysfunction. Inhibition of PI3K might be a useful approach in the therapeutics of vascular endothelium dysfunction.
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名称 | CAY10505 |
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Iupac 化学名称 | (E)-5-((5-(4-fluorophenyl)furan-2-yl)methylene)thiazolidine-2,4-dione |
同义词 | CAY10505; CAY 10505; CAY10505 |
英文同义词 | CAY10505; CAY 10505; CAY10505 |
分子式 | C14H8FNO3S |
分子量 | 289.28 |
Smile | FC1=CC=C(C=C1)C1=CC=C(O1)\C=C\1/C(NC(S1)=O)=O |
InChiKey | UFBTYTGRUBUUIL-KPKJPENVSA-N |
InChi | InChI=1S/C14H8FNO3S/c15-9-3-1-8(2-4-9)11-6-5-10(19-11)7-12-13(17)16-14(18)20-12/h1-7H,(H,16,17,18)/b12-7+ |
Cas号 | 1218777-13-9 |
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