CB-6644
编号: 41788
Cas号: 2316817-88-4
纯度: 96.33%
CB-6644 acts as a noncompetitive ATPase inhibitor. Additionally, it can inhibit RUVBL1/2 ATPase activity without blocking nucleotide binding. CB-6644 also interacts with the RUVBL1/2 complex in cells and induces cancer Ramos cell death. Besides, CB-6644 binds to and stabilizes RUVBL1/2 in Ramos cells.
仅供研究使用。 我们不向患者出售。
化学信息
| 名称 | CB-6644 |
|---|---|
| Iupac 化学名称 | 5-Chloro-2-ethoxy-4-fluoro-N-(4-((3-(methoxymethyl)-1-oxo-6,7-dihydro-1H,5H-benzo[c]pyrazolo[1,2-a][1,2]diazepin-2-yl)amino)-2,2-dimethyl-4-oxobutyl)benzamide |
| 同义词 | CB-6644 ; CB 6644 ; CB6644 |
| 英文同义词 | CB-6644 ; CB 6644 ; CB6644 |
| 分子式 | C29H34ClFN4O5 |
| 分子量 | 573.0624 |
| Smile | O=C(NCC(C)(C)CC(NC(C1=O)=C(COC)N2N1C3=CC=CC=C3CCC2)=O)C4=CC(Cl)=C(F)C=C4OCC |
| InChiKey | VYCOZEBCSAQCES-UHFFFAOYSA-N |
| InChi | InChI=1S/C29H34ClFN4O5/c1-5-40-24-14-21(31)20(30)13-19(24)27(37)32-17-29(2,3)15-25(36)33-26-23(16-39-4)34-12-8-10-18-9-6-7-11-22(18)35(34)28(26)38/h6-7,9,11,13-14H,5,8,10,12,15-17H2,1-4H3,(H,32,37)(H,33,36) |
| Cas号 | 2316817-88-4 |
| 相关CAS号 | 2316817-88-4 |
订购信息
| 包装 | 价格 | 库存 | 纯度 | 备货期 |
|---|---|---|---|---|
| 大货 | 询价 | 询价 | 询价 |
| 外观性状 | 类白色固体 |
|---|---|
| 纯度 | 96.33% |
| 存储 | 短期（几天到几周）为0-4摄氏度，长期（几个月）为-20摄氏度 |
| 可溶性 | 可溶于DMSO |
| 处理方式 | Avoid inhalation, contact with eyes and skin. Avoid dust and aerosol formation. Use only in areas with appropriate exhaust ventilation. |
| 运输条件 | 作为非危险化学品在环境温度下装运。这种产品在正常运输和海关工作期间可以稳定几周 |
| 海关编码 | 2933999701 |
Coming soon.
| Targets | RUVBL1/2 Complex Inhibitor |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
1: Assimon VA, Tang Y, Vargas JD, Lee GJ, Wu ZY, Lou K, Yao B, Menon MK, Pios A, Perez KC, Madriaga A, Buchowiecki PK, Rolfe M, Shawver L, Jiao X, Le Moigne R, Zhou HJ, Anderson DJ. CB-6644 Is a Selective Inhibitor of the RUVBL1/2 Complex with Anticancer Activity. ACS Chem Biol. 2019 Feb 15;14(2):236-244. doi: 10.1021/acschembio.8b00904. Epub 2019 Jan 25. PubMed PMID: 30640450.
