CC-115 hydrochloride is a inhibitor of mTOR/DNA-PK (IC50= 21/ 13 nM).
CC-115 shows good PK profiles across multiple species with 53%, 76%, and 100% oral bioavailability in mouse, rat, and dog, respectively. CC-115, with favorable physicochemical and pharmacokinetic properties, demonstrates mTOR pathway inhibition and tumor growth inhibition, as well as a good safety profile, suitable for clinical development.
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名称 | CC-115 hydrochloride |
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Iupac 化学名称 | CC-115 (hydrochloride) |
分子式 | C16H17ClN8O |
分子量 | 372.81 |
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InChi | |
Cas号 | 1300118-55-1 |
相关CAS号 |
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