CPI-169 racemate is the racemate form of CPI-169, which is a novel and potent EZH2 inhibitor with IC50 <1 nM(inhibition of the catalytic activity of PRC2); decreases cellular levels of H3K27me3 with an EC50 of 70 nM, and triggers cell cycle arrest and apoptosis in a variety of cell lines.
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化学信息
名称 | CPI-169(racemate) |
同义词 | 1-(1-(1-(Ethylsulfonyl)piperidin-4-yl)ethyl)-N-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1H-indole-3-carboxamide |
英文同义词 | 1-(1-(1-(Ethylsulfonyl)piperidin-4-yl)ethyl)-N-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1H-indole-3-carboxamide |
分子式 | C27H36N4O5S |
分子量 | 528.66 |
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Cas号 | 1450655-76-1 |
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外观性状 | Solid powder |
纯度 | 97% |
存储 | -20 ºC for 3 years |
可溶性 | Soluble in DMSO |
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运输条件 | Shipped under ambient temperature |
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