Cerdulatinib (PRT062070)
编号: 16122917
Cas号: 1198300-79-6
纯度: 98%
Cerdulatinib, also known as PRT2070 and PRT062070, is a n ovel, oral, dual spleen tyrosine kinase (Syk) and janus kinase (JAK) inhibitor. Cerdulatinib preferentially inhibited JAK1 and JAK3 dependent cytokine mediated signaling and functional responses in various cell types. IL2 mediated STAT5 Y694 was inhibited with an IC50 of 0.27M, while IL4 mediated signaling to STAT6 Y641 and functional responses in B cells and monocytes, namely CD69, CD25, and CD23 up-regulation, were inhibited with IC50Âs within the range of 0.11M to 0.57M. It is currently being studied in patients with genetically-defined hematologic cancers, as well as for patients who have failed therapy due to relapse or acquired mutations.
仅供研究使用。 我们不向患者出售。
化学信息
| 名称 | Cerdulatinib (PRT062070) |
|---|---|
| Iupac 化学名称 | Cerdulatinib (PRT062070) |
| 同义词 | PRT2070; PRT-2070; PRT 2070; PRT062070; PRT 062070; PRT-062070 |
| 英文同义词 | PRT2070; PRT-2070; PRT 2070; PRT062070; PRT 062070; PRT-062070 |
| 分子式 | C20H27N7O3S |
| 分子量 | 445.54 |
| InChiKey | |
| InChi | |
| Cas号 | 1198300-79-6 |
| 相关CAS号 |
订购信息
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