Cobicistat is a potent inhibitor of cytochrome P450 3A enzymes, including the important CYP3A4 subtype. It also inhibits intestinal transport proteins, increasing the overall absorption of several HIV medications, including atazanavir, darunavir and tenofovir alafenamide fumarate.
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名称 | Cobicistat(GS-9350) |
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Iupac 化学名称 | 2,7,10,12-Tetraazatridecanoic acid, 12-methyl-13-[2-(1-methylethyl)-4-thiazolyl]-9-[2-(4-morpholinyl)ethyl]-8,11-dioxo-3,6-bis(phenylmethyl)-, 5-thiazolylmethyl ester, (3R,6R,9S)- |
同义词 | Cobicistat;GS-9350;Tybost(trade name);GS9350;GS 9350 |
英文同义词 | Cobicistat;GS-9350;Tybost(trade name);GS9350;GS 9350 |
分子式 | C40H53N7O5S2 |
分子量 | 776.02 |
Smile | O=C(OCC1=CN=CS1)N[C@@H](CC2=CC=CC=C2)CC[C@H](CC3=CC=CC=C3)NC([C@H](CCN4CCOCC4)NC(N(C)CC5=CSC(C(C)C)=N5)=O)=O |
InChiKey | ZCIGNRJZKPOIKD-CQXVEOKZSA-N |
InChi | InChI=1S/C40H53N7O5S2/c1-29(2)38-43-34(27-53-38)25-46(3)39(49)45-36(16-17-47-18-20-51-21-19-47)37(48)42-32(22-30-10-6-4-7-11-30)14-15-33(23-31-12-8-5-9-13-31)44-40(50)52-26-35-24-41-28-54-35/h4-13,24,27-29,32-33,36H,14-23,25-26H2,1-3H3,(H,42,48)(H,44,50)(H,45,49)/t32-,33-,36+/m1/s1 |
Cas号 | 1004316-88-4 |
相关CAS号 |
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