Coralyne chloride
Coralyne chloride is a a protoberberine alkaloid, can be used as a fluorescent DNA-based molecular rectifier. Coralyne constructs into a DNA duplex by site-specific intercalation. Coralyne is a useful fluorescent probe for the sensitive and selective detection of heparin, DNA, nucleic acid, etc. Coralyne is also a promising antitumor and necurodrug.
仅供研究使用。 我们不向患者出售。
化学信息
| 名称 | Coralyne chloride |
|---|---|
| Iupac 化学名称 | 2,3,10,11-Tetramethoxy-8-methylisoquinolino[2,1-b]isoquinolin-7-ium chloride |
| 同义词 | Coralyne chloride; NSC 154890; NSC-154890; NSC154890; |
| 英文同义词 | Coralyne chloride; NSC 154890; NSC-154890; NSC154890; |
| 分子式 | C22H22ClNO4 |
| 分子量 | 399.87 |
| Smile | CC1=C2C=C(OC)C(OC)=CC2=CC3=C4C=C(OC)C(OC)=CC4=CC=[N+]13.[Cl-] |
| InChiKey | PDYBUYVOPAJLKP-UHFFFAOYSA-M |
| InChi | InChI=1S/C22H22NO4.ClH/c1-13-16-11-21(26-4)20(25-3)10-15(16)8-18-17-12-22(27-5)19(24-2)9-14(17)6-7-23(13)18;/h6-12H,1-5H3;1H/q+1;/p-1 |
| Cas号 | 38989-38-7 |
| 相关CAS号 |
订购信息
| 包装 | 价格 | 库存 | 纯度 | 备货期 |
|---|---|---|---|---|
| 大货 | 询价 | 询价 | 询价 |
| 外观性状 | 固体粉末 |
|---|---|
| 纯度 | 98% Min. |
| 存储 | 短期（几天到几周）为0-4摄氏度，长期（几个月）为-20摄氏度 |
| 可溶性 | 可溶于DMSO |
| 处理方式 | |
| 运输条件 | 作为非危险化学品在环境温度下装运。这种产品在正常运输和海关工作期间可以稳定几周 |
| 海关编码 |
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
1: Padmapriya K, Barthwal R. Nuclear magnetic resonance based structure of the protoberberine alkaloid coralyne and its self-association by spectroscopy techniques. J Pharm Anal. 2019 Dec;9(6):437-448. doi: 10.1016/j.jpha.2019.09.006. Epub 2019 Sep 26. PMID: 31890344; PMCID: PMC6931075.
2: Ma C, Chen M, He H, Chen L. Detection of coralyne and heparin by polymerase extension reaction using SYBR Green I. Mol Cell Probes. 2019 Aug;46:101423. doi: 10.1016/j.mcp.2019.101423. Epub 2019 Jul 16. PMID: 31323319.
3: Kumari S, Mohan MG, Shailender G, Badana AK, Malla RR. Synergistic enhancement of apoptosis by coralyne and paclitaxel in combination on MDA-MB-231 a triple-negative breast cancer cell line. J Cell Biochem. 2019 Oct;120(10):18104-18116. doi: 10.1002/jcb.29114. Epub 2019 Jun 6. PMID: 31172606.
4: Patro BS, Bhattacharyya R, Gupta P, Bandyopadhyay S, Chattopadhyay S. Mechanism of coralyne-mediated DNA photo-nicking process. J Photochem Photobiol B. 2019 May;194:140-148. doi: 10.1016/j.jphotobiol.2019.03.011. Epub 2019 Mar 21. PMID: 30954873.
5: Lee CY, Lin SW, Wu YH, Hsieh YZ. Combining DNA-stabilized silver nanocluster synthesis with exonuclease III amplification allows label-free detection of coralyne. Anal Chim Acta. 2018 Dec 26;1042:86-92. doi: 10.1016/j.aca.2018.08.030. Epub 2018 Aug 18. PMID: 30428992.
6: Wang Y, Sun X, Zeng J, Deng M, Li N, Chen Q, Zhu H, Liu F, Xing X. Label-free and sensitive detection assay for terminal deoxynucleotidyl transferase via polyadenosine-coralyne fluorescence enhancement strategy. Anal Biochem. 2019 Feb 15;567:85-89. doi: 10.1016/j.ab.2018.08.003. Epub 2018 Aug 26. PMID: 30157446.
7: Bhattacharyya R, Gupta P, Bandyopadhyay SK, Patro BS, Chattopadhyay S. Coralyne, a protoberberine alkaloid, causes robust photosenstization of cancer cells through ATR-p38 MAPK-BAX and JAK2-STAT1-BAX pathways. Chem Biol Interact. 2018 Apr 1;285:27-39. doi: 10.1016/j.cbi.2018.02.032. Epub 2018 Feb 24. PMID: 29486184.
8: Bhattacharyya R, Saha B, Tyagi M, Bandyopadhyay SK, Patro BS, Chattopadhyay S. Differential modes of photosensitisation in cancer cells by berberine and coralyne. Free Radic Res. 2017 Jul-Aug;51(7-8):723-738. doi: 10.1080/10715762.2017.1368506. Epub 2017 Sep 5. PMID: 28870132.
9: Pithan PM, Decker D, Druzhinin SI, Ihmels H, Schönherr H, Voß Y. 8-Styryl- substituted coralyne derivatives as DNA binding fluorescent probes. RSC Adv. 2017 Feb 8;7(18):10660-10667. doi: 10.1039/c6ra27684a. PMID: 28496973; PMCID: PMC5361113.
10: Kumari S, Badana AK, Mohan GM, Shailender Naik G, Malla R. Synergistic effects of coralyne and paclitaxel on cell migration and proliferation of breast cancer cells lines. Biomed Pharmacother. 2017 Jul;91:436-445. doi: 10.1016/j.biopha.2017.04.027. Epub 2017 May 2. PMID: 28475922.
11: Padmapriya K, Barthwal R. NMR based structural studies decipher stacking of the alkaloid coralyne to terminal guanines at two different sites in parallel G-quadruplex DNA, [d(TTGGGGT)]4 and [d(TTAGGGT)]4. Biochim Biophys Acta Gen Subj. 2017 Feb;1861(2):37-48. doi: 10.1016/j.bbagen.2016.11.011. Epub 2016 Nov 10. PMID: 27838396.
12: Padmapriya K, Barthwal R. Binding of the alkaloid coralyne to parallel G-quadruplex DNA [d(TTGGGGT)]4 studied by multi-spectroscopic techniques. Biophys Chem. 2016 Dec;219:49-58. doi: 10.1016/j.bpc.2016.09.006. Epub 2016 Oct 1. PMID: 27721081.
13: Padmapriya K, Barthwal R. Nuclear magnetic resonance studies reveal stabilization of parallel G-quadruplex DNA [d(T2G4T)]4 upon binding to protoberberine alkaloid coralyne. Bioorg Med Chem Lett. 2016 Oct 15;26(20):4915-4918. doi: 10.1016/j.bmcl.2016.09.016. Epub 2016 Sep 7. PMID: 27624081.
14: Kim KT, Choi TS, Kim KY, Kim HI, Kim BH. Disassembly of Chromophore-Guided DNA Duplexes through Site-Selective Binding of Coralyne to Pyrene-Modified Adenine Bases. Chempluschem. 2016 Jul;81(7):590-593. doi: 10.1002/cplu.201600230. Epub 2016 May 31. PMID: 31968721.
15: Li JJ, Xi Q, Du WF, Yu RQ, Jiang JH. Label-free fluorescence detection of microRNA based on target induced adenosine2-coralyne-adenosine2 formation. Analyst. 2016 Apr 21;141(8):2384-7. doi: 10.1039/c6an00001k. Epub 2016 Mar 21. PMID: 26998900.
16: Huang H, Shi S, Zheng X, Yao T. Sensitive detection for coralyne and mercury ions based on homo-A/T DNA by exonuclease signal amplification. Biosens Bioelectron. 2015 Sep 15;71:439-444. doi: 10.1016/j.bios.2015.04.076. Epub 2015 Apr 24. PMID: 25950941.
17: Chen M , Yang S , He X , Wang K , Qiu P , He D . Co-loading of coralyne and indocyanine green into adenine DNA-functionalized mesoporous silica nanoparticles for pH- and near-infrared-responsive chemothermal treatment of cancer cells. J Mater Chem B. 2014 Sep 28;2(36):6064-6071. doi: 10.1039/c4tb01040j. Epub 2014 Aug 6. PMID: 32261858.
18: Wang G, Zhu Y, Chen L, Zhang X. Dual hairpin-like molecular beacon based on coralyne-adenosine interaction for sensing melamine in dairy products. Talanta. 2014 Nov;129:398-403. doi: 10.1016/j.talanta.2014.05.046. Epub 2014 Jun 11. PMID: 25127611.
19: Zheng Y, Zhou J, Sayre DA, Sintim HO. Identification of bromophenol thiohydantoin as an inhibitor of DisA, a c-di-AMP synthase, from a 1000 compound library, using the coralyne assay. Chem Commun (Camb). 2014 Oct 4;50(76):11234-7. doi: 10.1039/c4cc02916j. PMID: 25116237.
20: Kan Y, Jiang C, Xi Q, Wang X, Peng L, Jiang J, Yu R. A simple, sensitive colorimetric assay for coralyne based on target induced split G-quadruplex formation. Anal Sci. 2014;30(5):561-8. doi: 10.2116/analsci.30.561. PMID: 24813954.
