DHPG, also known as (RS)-3,5-DHPG, is a selective agonist for group I metabotropic glutamate receptors (mGluRs), specifically targeting mGluR1 and mGluR5. Activation of these receptors by 3,5-DHPG has been shown to influence synaptic transmission and neuronal excitability. 3,5-DHPG, through its action on group I mGluRs, can modulate synaptic activity by promoting spontaneous neurotransmitter release in a patterned manner, which may have implications for understanding synaptic dynamics and developing therapeutic strategies targeting these receptors.
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名称 | DHPG |
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Iupac 化学名称 | 2-amino-2-(3,5-dihydroxyphenyl)acetic acid |
同义词 | DHPG; (RS)-3,5-DHPG |
英文同义词 | DHPG; (RS)-3,5-DHPG |
分子式 | C8H9NO4 |
分子量 | 183.16 |
Smile | O=C(O)C(N)C1=CC(O)=CC(O)=C1 |
InChiKey | HOOWCUZPEFNHDT-UHFFFAOYSA-N |
InChi | InChI=1S/C8H9NO4/c9-7(8(12)13)4-1-5(10)3-6(11)2-4/h1-3,7,10-11H,9H2,(H,12,13) |
Cas号 | 146255-66-5 |
相关CAS号 |
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