DM1-SMCC is DM1 with a reactive linker SMCC, which can react with antibody to make antibody drug conjugate. DM1 is an antibody-conjugatable maytansinoid that was developed to overcome systemic toxicity associated with maytansine and to enhance tumor-specific delivery. DM1 binds at the tips of microtubules and suppresses the dynamicity of microtubules.
仅供研究使用。 我们不向患者出售。
化学信息
名称 | DM1-SMCC |
Iupac 化学名称 | DM1-SMCC |
同义词 | DM1 SMCC; DM1SMCC. SMCC-DM1 |
英文同义词 | DM1 SMCC; DM1SMCC. SMCC-DM1 |
分子式 | C51H66ClN5O16S |
分子量 | 1072.618 |
InChiKey | |
InChi | |
Cas号 | 1228105-51-8 |
相关CAS号 | |
外观性状 | crystalline solid |
纯度 | 98% |
存储 | 3 years -20ºCpowder |
可溶性 | Soluble in DMSO |
处理方式 | |
运输条件 | Shipped under ambient temperature as non-hazardous chemical. |
海关编码 | |
Targets | |
Mechanism | |
Cell study | |
Animal study | |
Clinical study | |