DTHIB
DTHIB is a direct and selective heat shock factor 1 (HSF1) inhibitor with a Kd of 160 nM. DTHIB physically engages HSF1 and selectively stimulates degradation of nuclear HSF1. DTHIB robustly inhibited the HSF1 cancer gene signature and prostate cancer cell proliferation. In addition, it potently attenuated tumor progression in four therapy-resistant prostate cancer animal models, including an NEPC model, where it caused profound tumor regression.
仅供研究使用。 我们不向患者出售。
化学信息
| 名称 | DTHIB |
|---|---|
| Iupac 化学名称 | 1-(4-chloro-3-nitrophenyl)-3-(4-fluorophenyl)urea |
| 同义词 | DTHIB |
| 英文同义词 | DTHIB |
| 分子式 | C13H9ClFN3O3 |
| 分子量 | 309.6814 |
| Smile | O=C(NC1=CC=C(F)C=C1)NC2=CC=C(Cl)C([N+]([O-])=O)=C2 |
| InChiKey | DWVIOMKFHSRQQM-UHFFFAOYSA-N |
| InChi | InChI=1S/C13H9ClFN3O3/c14-11-6-5-10(7-12(11)18(20)21)17-13(19)16-9-3-1-8(15)2-4-9/h1-7H,(H2,16,17,19) |
| Cas号 | 897326-30-6 |
| 相关CAS号 |
订购信息
| 包装 | 价格 | 库存 | 纯度 | 备货期 |
|---|---|---|---|---|
| 大货 | 询价 | 询价 | 询价 |
| 纯度 | 98% Min. |
|---|---|
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| Clinical study |
Dong B, Jaeger AM, Hughes PF, Loiselle DR, Hauck JS, Fu Y, Haystead TA, Huang J, Thiele DJ. Targeting therapy-resistant prostate cancer via a direct inhibitor of the human heat shock transcription factor 1. Sci Transl Med. 2020 Dec 16;12(574):eabb5647. doi: 10.1126/scitranslmed.abb5647. PMID: 33328331.
