Decoglurant
编号: 2071542
Cas号: 911115-16-7
纯度: 98% Min.
Decoglurant, also known as Ro 4995819, is a negative allosteric modulator of the mGlu2 and mGlu3 receptors which was under development by Roche for the adjunctive treatment of major depressive disorder. Decoglurant progressed as far as phase II clinical trials but was ultimately discontinued from further development due to disappointing efficacy results.
仅供研究使用。 我们不向患者出售。
化学信息
| 名称 | Decoglurant |
|---|---|
| Iupac 化学名称 | 5-((7-(trifluoromethyl)-5-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)ethynyl)pyridin-2-amine |
| 同义词 | Ro-4995819; Ro4995819; Ro4995819; Decoglurant. |
| 英文同义词 | Ro-4995819; Ro4995819; Ro4995819; Decoglurant. |
| 分子式 | C21H11F6N5 |
| 分子量 | 447.3444 |
| Smile | NC1=NC=C(C#CC2=C3N=C(C4=CC=C(C(F)(F)F)C=C4)C=C(C(F)(F)F)N3N=C2)C=C1 |
| InChiKey | DMJHZVARRXJSEG-UHFFFAOYSA-N |
| InChi | InChI=1S/C21H11F6N5/c22-20(23,24)15-6-4-13(5-7-15)16-9-17(21(25,26)27)32-19(31-16)14(11-30-32)3-1-12-2-8-18(28)29-10-12/h2,4-11H,(H2,28,29) |
| Cas号 | 911115-16-7 |
| 相关CAS号 |
订购信息
| 包装 | 价格 | 库存 | 纯度 | 备货期 |
|---|---|---|---|---|
| 大货 | 询价 | 询价 | 询价 |
| 外观性状 | 固体粉末 |
|---|---|
| 纯度 | 98% Min. |
| 存储 | 短期（几天到几周）为0-4摄氏度，长期（几个月）为-20摄氏度 |
| 可溶性 | 可溶于DMSO |
| 处理方式 | |
| 运输条件 | 作为非危险化学品在环境温度下装运。这种产品在正常运输和海关工作期间可以稳定几周 |
| 海关编码 |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
1: Javelot H. [Psychopharmacology of anxiety and depression: Historical aspects,
current treatments and perspectives]. Ann Pharm Fr. 2015 Oct 12. pii:
S0003-4509(15)00110-8. doi: 10.1016/j.pharma.2015.09.001. [Epub ahead of print]
Review. French. PubMed PMID: 26472602.
