Dinaciclib is a novel potent small molecule inhibitor of cyclin-dependent kinases (CDK)1, CDK2, CDK5, and CDK9. Patients with relapsed multiple myeloma and 5 prior lines of therapy, with measurable disease, were enrolled.
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名称 | Dinaciclib(SCH-727965) |
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Iupac 化学名称 | (S)-3-(((3-Ethyl-5-(2-(2-hydroxyethyl)piperidin-1-yl)pyrazolo[1,5-a]pyrimidin-7-yl)amino)methyl)pyridine 1-oxide |
同义词 | SCH727965 |
英文同义词 | SCH727965 |
分子式 | C21H28N6O2 |
分子量 | 396.49 |
Smile | C(C)C=1C=NN2C1N=C(C=C2NCC=2C=[N+](C=CC2)[O-])N2[C@@H](CCCC2)CCO |
InChiKey | PIMQWRZWLQKKBJ-SFHVURJKSA-N |
InChi | InChI=1S/C21H28N6O2/c1-2-17-14-23-27-19(22-13-16-6-5-9-25(29)15-16)12-20(24-21(17)27)26-10-4-3-7-18(26)8-11-28/h5-6,9,12,14-15,18,22,28H,2-4,7-8,10-11,13H2,1H3/t18-/m0/s1 |
Cas号 | 779353-01-4 |
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