Dolutegravir Sodium
编号: 16122764
Cas号: 1051375-19-9
纯度: 98%
Dolutegravir is a HIV integrase inhibitor with IC50 of 2.7 nM.Dolutegravir(S/GSK1349572) inhibits HIV-1 integrase-catalyzed strand transfer with a 50% inhibitory concentration (IC50) of 2.7 nM. S/GSK1349572 inhibits both the HIV integration reaction strand transfer step in vitro and HIV replication in cells with similar potencies. The inhibitor has no effect on total viral DNA synthesis in infected cells but blocks the integration of viral DNA into host DNA with the same potency as its antiviral effect
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化学信息
| 名称 | Dolutegravir Sodium |
|---|---|
| Iupac 化学名称 | Dolutegravir Sodium |
| 同义词 | GSK-1349572A |
| 英文同义词 | GSK-1349572A |
| 分子式 | C20H19F2N3O5.Na |
| 分子量 | 441.36 |
| Smile | FC1=C(CNC(=O)C=2C(C(=C3N(C[C@@H]4OCC[C@H](N4C3=O)C)C2)[O-])=O)C=CC(=C1)F.[Na+] |
| InChiKey | UGWJRRXTMKRYNK-VSLILLSYSA-M |
| InChi | InChI=1S/C20H19F2N3O5.Na/c1-10-4-5-30-15-9-24-8-13(17(26)18(27)16(24)20(29)25(10)15)19(28)23-7-11-2-3-12(21)6-14(11)22;/h2-3,6,8,10,15,27H,4-5,7,9H2,1H3,(H,23,28);/q;+1/p-1/t10-,15+;/m1./s1 |
| Cas号 | 1051375-19-9 |
| 相关CAS号 |
订购信息
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