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E7046

编号: 24055
Cas号: 1369489-71-3
纯度: 98% Min.

E7046 is a potent and selective antagonist of the type 4 prostaglandin E2 (PGE2) receptor EP4. EP4 Antagonism by E7046 diminishes Myeloid immunosuppression and synergizes with Treg-reducing IL-2-Diphtheria toxin fusion protein in restoring anti-tumor immunity. E7046 has specific and potent inhibitory activity on PGE2-mediated pro-tumor myeloid cell differentiation and activation. E7046 treatment reduced the growth or even rejected established tumors in vivo in a manner dependent on both myeloid and CD8+ T cells.

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化学信息

名称E7046
Iupac 化学名称 4-[(1S)-1-[[[3-(difluoromethyl)-1-methyl-5-[3-(trifluoromethyl)phenoxy]-1H-pyrazol-4-yl]carbonyl]amino]ethyl]-benzoic acid
同义词E7046; E-7046; E 7046.
英文同义词E7046; E-7046; E 7046.
分子式C22H18F5N3O4
分子量483.39
SmileO=C(O)C1=CC=C([C@@H](NC(C2=C(OC3=CC=CC(C(F)(F)F)=C3)N(C)N=C2C(F)F)=O)C)C=C1
InChiKeyMKLKAQMPKHNQPR-NSHDSACASA-N
InChiInChI=1S/C22H18F5N3O4/c1-11(12-6-8-13(9-7-12)21(32)33)28-19(31)16-17(18(23)24)29-30(2)20(16)34-15-5-3-4-14(10-15)22(25,26)27/h3-11,18H,1-2H3,(H,28,31)(H,32,33)/t11-/m0/s1
Cas号1369489-71-3
相关CAS号

订购信息

包装价格库存纯度备货期
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Request Bulk Quote Download MSDS 电话 : +86-177 0271 9238   Email : sales@sun-shinechem.com
外观性状类白色固体
纯度98% Min.
存储 0-4℃,可保存几天到几周;-20℃,可保存 几个月。
可溶性溶于DMSO等有机溶剂
处理方式Refer to MSDS
运输条件可以在室温下进行运输。
海关编码2934200090
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study

1: Albu DI, Wang Z, Huang KC, Wu J, Twine N, Leacu S, Ingersoll C, Parent L, Lee W, Liu D, Wright-Michaud R, Kumar N, Kuznetsov G, Chen Q, Zheng W, Nomoto K, Woodall-Jappe M, Bao X. EP4 Antagonism by E7046 diminishes Myeloid immunosuppression and synergizes with Treg-reducing IL-2-Diphtheria toxin fusion protein in restoring anti-tumor immunity. Oncoimmunology. 2017 Jun 28;6(8):e1338239. doi: 10.1080/2162402X.2017.1338239. eCollection 2017. PubMed PMID: 28920002; PubMed Central PMCID: PMC5593700.

2: Wan J, Zhang L, Lu G, Gu W, Huang L, Ge L, Zhang X, Ji L, Chen Q, Di R, Jiang Y. Midterm outcomes of intracranial aneurysms with bleb formation with densely coiling of the aneurismal neck or entire aneurysm. Medicine (Baltimore). 2017 Aug;96(33):e7046. doi: 10.1097/MD.0000000000007046. PubMed PMID: 28816934; PubMed Central PMCID: PMC5571671.

3: Noroozi Karimabad M, Hassanshahi G, Arababadi MK. Controversial report regarding seroprevalence of hepatitis B and C viruses among hemodialysis patients in kerman province, South-East iran. Hepat Mon. 2013 Mar 13;13(3):e7046. doi: 10.5812/hepatmon.7046. Print 2013 Mar. PubMed PMID: 23675385; PubMed Central PMCID: PMC3651842.

4: Gustafsson MC, Knight D, Palmer CN. Ligand modulated antagonism of PPARgamma by genomic and non-genomic actions of PPARdelta. PLoS One. 2009 Sep 16;4(9):e7046. doi: 10.1371/journal.pone.0007046. PubMed PMID: 19756148; PubMed Central PMCID: PMC2737640.

化学结构

24055 - E7046 | CAS 1369489-71-3

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