ETC-159
编号: 16060301
Cas号: 1638250-96-0
纯度: 98% by HPLC
ETC-159, also known as ETC-1922159, is a potent, selective and orally available PORCN inhibitor. ETC-159 blocks the secretion and activity of all Wnts. ETC-159 is remarkably effective in treating RSPO-translocation bearing colorectal cancer (CRC) patient-derived xenografts. Inhibition of Wnt signaling by PORCN inhibition holds promise as differentiation therapy in genetically defined human cancers. Enhanced sensitivity to Wnts is an emerging hallmark of a subset of cancers, defined in part by mutations regulating the abundance of their receptors
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化学信息
| 名称 | ETC-159 |
|---|---|
| Iupac 化学名称 | 1,3-dimethyl-7-((6-phenylpyridazin-3-yl)glycyl)-3,4,5,7-tetrahydro-1H-purine-2,6-dione |
| 同义词 | ETC 159; ETC-1922159 |
| 英文同义词 | ETC 159; ETC-1922159 |
| 分子式 | C19H19N7O3 |
| 分子量 | 393.407 |
| Smile | CN1C(N(C2N=CN(C2C1=O)C(CNC=1N=NC(=CC1)C1=CC=CC=C1)=O)C)=O |
| InChiKey | COEZTQWWLJCBEC-UHFFFAOYSA-N |
| InChi | InChI=1S/C19H19N7O3/c1-24-17-16(18(28)25(2)19(24)29)26(11-21-17)15(27)10-20-14-9-8-13(22-23-14)12-6-4-3-5-7-12/h3-9,11,16-17H,10H2,1-2H3,(H,20,23) |
| Cas号 | 1638250-96-0 |
| 相关CAS号 |
订购信息
| 包装 | 价格 | 库存 | 纯度 | 备货期 |
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| 大货 | 询价 | 询价 | 询价 |
