EXP-3174
编号: 16122943
Cas号: 124750-92-1
纯度: 98%
EXP-3174, also known as Losartan Carboxylic Acid, is a physiologically active metabolite of losartan, produced by cytochrome P450 isoforms in the liver. Like the parent compound, EXP-3174 is a potent AT1 antagonist (Kis = 0.57 and 0.67 nM for rat and human forms, respectively), producing a depressor response and vasodilatation. When administered intravenously, losartan carboxylic acid is more potent and has a longer duration of action than losartan. However, the metabolite has very low oral bioavailability.
仅供研究使用。 我们不向患者出售。
化学信息
| 名称 | EXP-3174 |
|---|---|
| Iupac 化学名称 | EXP-3174 |
| 同义词 | EXP 3174; EXP3174; E-3174; E 3174; E3174; Losartan Carboxylic Acid |
| 英文同义词 | EXP 3174; EXP3174; E-3174; E 3174; E3174; Losartan Carboxylic Acid |
| 分子式 | C22H21ClN6O2 |
| 分子量 | 436.9 |
| Smile | [2H]c1c(c(c(c(c1Cn2c(nc(c2C(=O)O)Cl)CCCC)[2H])[2H])c3ccccc3c4[nH]nnn4)[2H] |
| InChiKey | ZEUXAIYYDDCIRX-IRYCTXJYSA-N |
| InChi | InChI=1S/C22H21ClN6O2/c1-2-3-8-18-24-20(23)19(22(30)31)29(18)13-14-9-11-15(12-10-14)16-6-4-5-7-17(16)21-25-27-28-26-21/h4-7,9-12H,2-3,8,13H2,1H3,(H,30,31)(H,25,26,27,28)/i9D,10D,11D,12D |
| Cas号 | 124750-92-1 |
| MDL | MFCD08063458 |
| 相关CAS号 |
订购信息
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