Elvitegravir (EVG, formerly GS-9137) is an integrase inhibitor used to treat HIV infection.It was developed by the pharmaceutical company Gilead Sciences, which licensed EVG from Japan Tobacco in March 2008. The drug gained approval by the U.S. FDA on August 27, 2012 for use in adult patients starting HIV treatment for the first time as part of the fixed dose combination known as Stribild.
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名称 | Elvitegravir(GS-9137) |
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Iupac 化学名称 | (S)-6-(3-chloro-2-fluorobenzyl)-1-(1-hydroxy-3-methylbutan-2-yl)-7-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid |
同义词 | JTK-303 |
英文同义词 | JTK-303 |
分子式 | C23H23ClFNO5 |
分子量 | 447.88 |
Smile | ClC=1C(=C(CC=2C=C3C(C(=CN(C3=CC2OC)[C@H](CO)C(C)C)C(=O)O)=O)C=CC1)F |
InChiKey | JUZYLCPPVHEVSV-LJQANCHMSA-N |
InChi | InChI=1S/C23H23ClFNO5/c1-12(2)19(11-27)26-10-16(23(29)30)22(28)15-8-14(20(31-3)9-18(15)26)7-13-5-4-6-17(24)21(13)25/h4-6,8-10,12,19,27H,7,11H2,1-3H3,(H,29,30)/t19-/m1/s1 |
Cas号 | 697761-98-1 |
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