Eprodisate, also known as 3-PDS; NC-503; 3PDS, is an orally available disodium salt form of eprodisate, a negatively charged sulfonated inhibitor of fibrillogenesis, that can be used in the treatment of amyloid A (AA) amyloidosis. Upon administration, eprodisate competitively binds to the glycosaminoglycan binding sites on serum amyloid A (SAA), which inhibits the formation of the glycosaminoglycan-amyloid fibril aggregate. This prevents the formation of amyloid deposits in certain organs, especially the kidneys, in AA amyloidosis.
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化学信息
名称 | Eprodisate Sodium |
Iupac 化学名称 | Eprodisate Sodium |
同义词 | 3-PDS; NC-503; 3PDS; Eprodisate Sodium; Kiacta |
英文同义词 | 3-PDS; NC-503; 3PDS; Eprodisate Sodium; Kiacta |
分子式 | C3H6Na2O6S2 |
分子量 | 248.1745 |
Smile | C(CS(=O)(=O)[O-])CS(=O)(=O)[O-].[Na+].[Na+] |
InChiKey | DKGJFKPIUSHDIT-UHFFFAOYSA-L |
InChi | InChI=1S/C3H8O6S2.2Na/c4-10(5,6)2-1-3-11(7,8)9;;/h1-3H2,(H,4,5,6)(H,7,8,9);;/q;2*+1/p-2 |
Cas号 | 36589-58-9 |
MDL | MFCD00191483 |
相关CAS号 | |
外观性状 | crystalline solid |
纯度 | 98% |
存储 | 3 years -20ºCpowder |
可溶性 | Soluble in DMSO |
处理方式 | |
运输条件 | Shipped under ambient temperature as non-hazardous chemical. |
海关编码 | |
Targets | |
Mechanism | |
Cell study | |
Animal study | |
Clinical study | |