Etamicastat, also known as BIA 5-453, is a potent, reversible, peripherally selective dopamine -hydroxylase inhibitor (DBH inhibitor). Chronic dopamine ß-hydroxylase inhibition with etamicastat effectively decreases blood pressure, although does not prevent the development of hypertension in the spontaneously hypertensive rat.
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化学信息
名称 | Etamicastat HCl salt |
Iupac 化学名称 | (R)-5-(2-aminoethyl)-1-(6,8-difluorochroman-3-yl)-1,3-dihydro-2H-imidazole-2-thione hydrochloride |
同义词 | BIA 5-453; BIA5-453 |
英文同义词 | BIA 5-453; BIA5-453 |
分子式 | C14H16ClF2N3OS |
分子量 | 347.8088 |
Smile | Cl.NCCC1=CNC(N1[C@H]1COC2=C(C=C(C=C2C1)F)F)=S |
InChiKey | CKRDOSZCFINPAD-RFVHGSKJSA-N |
InChi | InChI=1S/C14H15F2N3OS.ClH/c15-9-3-8-4-11(7-20-13(8)12(16)5-9)19-10(1-2-17)6-18-14(19)21;/h3,5-6,11H,1-2,4,7,17H2,(H,18,21);1H/t11-;/m1./s1 |
Cas号 | 677773-32-9 |
相关CAS号 | |
外观性状 | Solid powder |
纯度 | 98% by HPLC |
存储 | -20 ºC for 3 years |
可溶性 | Soluble in DMSO |
处理方式 | |
运输条件 | Shipped under ambient temperature |
海关编码 | |
Targets | |
Mechanism | |
Cell study | |
Animal study | |
Clinical study | |