Etravirine (TMC125) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used for the treatment of HIV.Etravirine (TMC125), is highly active against wild-type HIV-1 with EC50 of 1.4 nM to 4.8 nM and shows some activity against HIV-2 with EC50 of 3.5 M. TMC125 also inhibits a series of HIV-1 group M subtypes and circulating recombinant forms and a group O virus.
仅供研究使用。 我们不向患者出售。
化学信息
名称 | Etravirine (TMC125) |
Iupac 化学名称 | Etravirine (TMC125) |
同义词 | R-165335 |
英文同义词 | R-165335 |
分子式 | C20H15BrN6O |
分子量 | 435.28 |
Smile | Cc1cc(cc(c1Oc2c(c(nc(n2)Nc3ccc(cc3)C#N)N)Br)C)C#N |
InChiKey | PYGWGZALEOIKDF-UHFFFAOYSA-N |
InChi | InChI=1S/C20H15BrN6O/c1-11-7-14(10-23)8-12(2)17(11)28-19-16(21)18(24)26-20(27-19)25-15-5-3-13(9-22)4-6-15/h3-8H,1-2H3,(H3,24,25,26,27) |
Cas号 | 269055-15-4 |
MDL | MFCD09837879 |
相关CAS号 | |
外观性状 | crystalline solid |
纯度 | 98% |
存储 | 3 years -20ºCpowder |
可溶性 | Soluble in DMSO |
处理方式 | |
运输条件 | Shipped under ambient temperature as non-hazardous chemical. |
海关编码 | |
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Mechanism | |
Cell study | |
Animal study | |
Clinical study | |