FG-2216, also known as YM311, is orally bioavailable HIF-prolyl hydroxylase inhibitor. FG-2216 induced significant and reversible Epo induction in vivo. FG-2216 showed the ability to stabilize HIF-, to stimulate EPO secretion in in vitro studies, and to increase hematocrit, red blood cell count, and hemoglobin levels in an animal efficacy study.
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化学信息
名称 | FG-2216 |
Iupac 化学名称 | FG-2216 |
同义词 | FG 2216; FG2216; YM311; YM-311; YM 311 |
英文同义词 | FG 2216; FG2216; YM311; YM-311; YM 311 |
分子式 | C12H9ClN2O4 |
分子量 | 280.664 |
Smile | c1ccc2c(c1)c(c(nc2Cl)C(=O)NCC(=O)O)O |
InChiKey | OUQVKRKGTAUJQA-UHFFFAOYSA-N |
InChi | InChI=1S/C12H9ClN2O4/c13-11-7-4-2-1-3-6(7)10(18)9(15-11)12(19)14-5-8(16)17/h1-4,18H,5H2,(H,14,19)(H,16,17) |
Cas号 | 223387-75-5 |
MDL | MFCD23136998 |
相关CAS号 | |
外观性状 | crystalline solid |
纯度 | 98% |
存储 | 3 years -20ºCpowder |
可溶性 | Soluble in DMSO |
处理方式 | |
运输条件 | Shipped under ambient temperature as non-hazardous chemical. |
海关编码 | |
Targets | |
Mechanism | |
Cell study | |
Animal study | |
Clinical study | |