FG-7142
FG-7142 is a benzodiazepine receptor ligand with anxiogenic and proconvulsant properties.
仅供研究使用。 我们不向患者出售。
化学信息
| 名称 | FG-7142 |
|---|---|
| Iupac 化学名称 | N-methyl-9H-pyrido[3,4-b]indole-3-carboxamide |
| 同义词 | FG-7142; FG 7142; FG7142; |
| 英文同义词 | FG-7142; FG 7142; FG7142; |
| 分子式 | C13H11N3O |
| 分子量 | 225.251 |
| Smile | O=C(C1=CC2=C(C=N1)NC3=C2C=CC=C3)NC |
| InChiKey | QMCOPDWHWYSJSA-UHFFFAOYSA-N |
| InChi | InChI=1S/C13H11N3O/c1-14-13(17)11-6-9-8-4-2-3-5-10(8)16-12(9)7-15-11/h2-7,16H,1H3,(H,14,17) |
| Cas号 | 78538-74-6 |
| 相关CAS号 |
订购信息
| 包装 | 价格 | 库存 | 纯度 | 备货期 |
|---|---|---|---|---|
| 大货 | 询价 | 询价 | 询价 |
| 外观性状 | 固体粉末 |
|---|---|
| 纯度 | 98% Min. |
| 存储 | 短期（几天到几周）为0-4摄氏度，长期（几个月）为-20摄氏度 |
| 可溶性 | 可溶于DMSO |
| 处理方式 | |
| 运输条件 | 作为非危险化学品在环境温度下装运。这种产品在正常运输和海关工作期间可以稳定几周 |
| 海关编码 |
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
1: Horowski R. FG 7142: is this validated tool to study anxiety now forgotten? J Neural Transm (Vienna). 2020 Feb;127(2):287-289. doi: 10.1007/s00702-019-02136-3. Epub 2020 Jan 11. PMID: 31927622.
2: Kurumaji A, Nishikawa T. An anxiogenic drug, FG 7142, induced an increase in mRNA of Btg2 and Adamts1 in the hippocampus of adult mice. Behav Brain Funct. 2012 Aug 22;8:43. doi: 10.1186/1744-9081-8-43. PMID: 22913326; PMCID: PMC3541064.
3: Waters RP, See RE. Chronic cocaine self-administration attenuates the anxiogenic-like and stress potentiating effects of the benzodiazepine inverse agonist, FG 7142. Pharmacol Biochem Behav. 2011 Sep;99(3):408-13. doi: 10.1016/j.pbb.2011.05.021. Epub 2011 May 24. PMID: 21635914; PMCID: PMC3129491.
4: Martire SI, Parkes SL, Westbrook RF. The effects of FG 7142 on sensory- specific satiety in rats. Behav Brain Res. 2010 May 1;209(1):131-6. doi: 10.1016/j.bbr.2010.01.034. Epub 2010 Jan 29. PMID: 20117147.
5: Sink KS, Segovia KN, Sink J, Randall PA, Collins LE, Correa M, Markus EJ, Vemuri VK, Makriyannis A, Salamone JD. Potential anxiogenic effects of cannabinoid CB1 receptor antagonists/inverse agonists in rats: comparisons between AM4113, AM251, and the benzodiazepine inverse agonist FG-7142. Eur Neuropsychopharmacol. 2010 Feb;20(2):112-22. doi: 10.1016/j.euroneuro.2009.11.002. Epub 2009 Dec 16. PMID: 20015619; PMCID: PMC2817975.
6: Stevenson CW, Marsden CA, Mason R. Early life stress causes FG-7142-induced corticolimbic dysfunction in adulthood. Brain Res. 2008 Feb 8;1193:43-50. doi: 10.1016/j.brainres.2007.11.062. Epub 2007 Dec 8. PMID: 18190899.
7: Stevenson CW, Halliday DM, Marsden CA, Mason R. Systemic administration of the benzodiazepine receptor partial inverse agonist FG-7142 disrupts corticolimbic network interactions. Synapse. 2007 Aug;61(8):646-63. doi: 10.1002/syn.20414. PMID: 17503486.
8: Cottone P, Sabino V, Steardo L, Zorrilla EP. FG 7142 specifically reduces meal size and the rate and regularity of sustained feeding in female rats: evidence that benzodiazepine inverse agonists reduce food palatability. Neuropsychopharmacology. 2007 May;32(5):1069-81. doi: 10.1038/sj.npp.1301229. Epub 2006 Nov 1. PMID: 17077811.
9: Evans AK, Abrams JK, Bouwknecht JA, Knight DM, Shekhar A, Lowry CA. The anxiogenic drug FG-7142 increases serotonin metabolism in the rat medial prefrontal cortex. Pharmacol Biochem Behav. 2006 Jun;84(2):266-74. doi: 10.1016/j.pbb.2006.05.007. Epub 2006 Jun 19. PMID: 16784772.
10: Claustre Y, Rouquier L, Desvignes C, Leonetti M, Montégut J, Aubin N, Allouard N, Bougault I, Oury-Donat F, Steinberg R. Effects of the vasopressin (V1b) receptor antagonist, SSR149415, and the corticotropin-releasing factor 1 receptor antagonist, SSR125543, on FG 7142-induced increase in acetylcholine and norepinephrine release in the rat. Neuroscience. 2006 Sep 1;141(3):1481-8. doi: 10.1016/j.neuroscience.2006.05.006. Epub 2006 Jun 15. PMID: 16781820.
11: Salchner P, Sartori SB, Sinner C, Wigger A, Frank E, Landgraf R, Singewald N. Airjet and FG-7142-induced Fos expression differs in rats selectively bred for high and low anxiety-related behavior. Neuropharmacology. 2006 Jun;50(8):1048-58. doi: 10.1016/j.neuropharm.2006.02.008. Epub 2006 Apr 19. PMID: 16620881.
12: Jaskiw GE, Lipska BK, Weinberger DR. The anxiogenic beta-carboline FG-7142 inhibits locomotor exploration similarly in postweanling and adult rats. Neurosci Lett. 2003 Jul 31;346(1-2):5-8. doi: 10.1016/s0304-3940(03)00384-7. PMID: 12850534.
13: Horowski R, Dorrow R. Anxiogenic, not psychotogenic, properties of the partial inverse benzodiazepine receptor agonist FG 7142 in man. Psychopharmacology (Berl). 2002 Jul;162(2):223-4. doi: 10.1007/s00213-002-1095-1. PMID: 12197487.
14: Dazzi L, Vignone V, Seu E, Ladu S, Vacca G, Biggio G. Inhibition by venlafaxine of the increase in norepinephrine output in rat prefrontal cortex elicited by acute stress or by the anxiogenic drug FG 7142. J Psychopharmacol. 2002 Jun;16(2):125-31. doi: 10.1177/026988110201600202. PMID: 12095070.
15: Dazzi L, Vacca G, Ladu S, Pisu MG, Serra M, Biggio G. Long-term treatment with antidepressant drugs reduces the sensitivity of cortical cholinergic neurons to the activating actions of stress and the anxiogenic drug FG 7142. Neuropharmacology. 2001 Aug;41(2):229-37. doi: 10.1016/s0028-3908(01)00064-8. PMID: 11489459.
16: Jaskiw GE, Lipska BK, Karoum F, Weinberger DR. Exposure of a 'witness rat' to one treated with beta-carboline FG 7142 does not increase dopamine turnover in the medial prefrontal cortex of the 'witness rat'. Neurosci Lett. 2001 Apr 20;302(2-3):151-3. doi: 10.1016/s0304-3940(01)01689-5. PMID: 11290409.
17: Adamec RE. Evidence that long-lasting potentiation of amygdala efferents in the right hemisphere underlies pharmacological stressor (FG-7142) induced lasting increases in anxiety-like behaviour: role of GABA tone in initiation of brain and behavioural changes. J Psychopharmacol. 2000;14(4):323-39. doi: 10.1177/026988110001400418. PMID: 11198049.
18: Adamec RE. Evidence that long-lasting potentiation in limbic circuits mediating defensive behaviour in the right hemisphere underlies pharmacological stressor (FG-7142) induced lasting increases in anxiety-like behaviour: role of benzodiazepine receptors. J Psychopharmacol. 2000;14(4):307-22. doi: 10.1177/026988110001400401. PMID: 11198048.
19: Adamec RE. Evidence that NMDA-dependent limbic neural plasticity in the right hemisphere mediates pharmacological stressor (FG-7142)-induced lasting increases in anxiety-like behavior: study 3--the effects on amygdala efferent physiology of block of NMDA receptors prior to injection of FG-7142 and its relationship to behavioral change. J Psychopharmacol. 1998;12(3):227-38. doi: 10.1177/026988119801200301. PMID: 10958248.
20: Stowell JR, Berntson GG, Sarter M. Attenuation of the bidirectional effects of chlordiazepoxide and FG 7142 on conditioned response suppression and associated cardiovascular reactivity by loss of cortical cholinergic inputs. Psychopharmacology (Berl). 2000 Jun;150(2):141-9. doi: 10.1007/s002130000443. PMID: 10907667.
