GDC-0077
编号: L20335
Cas号: 2060571-02-8
纯度: 98% Min.
Inavolisib, also known as GDC-0077, is a potent and selective PI3K inhibitor. GDC-0077 blocks an enzyme involved in cancer growth called PI3K. GDC0077 binds to and inhibits various members of the PI3K family, including activating mutations in the catalytic alpha isoform PIK3CA. PI3K inhibition prevents the activation of the PI3K-mediated signaling pathway and results in the inhibition of growth and survival of PI3K-overexpressing tumor cells.
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化学信息
| 名称 | GDC-0077 |
|---|---|
| Iupac 化学名称 | (S)-2-((2-((S)-4-(difluoromethyl)-2-oxooxazolidin-3-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)amino)propanamide |
| 同义词 | GDC-0077; GDC 0077; GDC0077; Inavolisib; RG6114; RG 6114; RG-6114 |
| 英文同义词 | GDC-0077; GDC 0077; GDC0077; Inavolisib; RG6114; RG 6114; RG-6114 |
| 分子式 | C18H19F2N5O4 |
| 分子量 | 407.37 |
| Smile | C[C@@H](C(N)=O)NC1=CC=C(C2=NC(N3[C@H](C(F)F)COC3=O)=CN2CCO4)C4=C1 |
| InChiKey | SGEUNORSOZVTOL-CABZTGNLSA-N |
| InChi | InChI=1S/C18H19F2N5O4/c1-9(16(21)26)22-10-2-3-11-13(6-10)28-5-4-24-7-14(23-17(11)24)25-12(15(19)20)8-29-18(25)27/h2-3,6-7,9,12,15,22H,4-5,8H2,1H3,(H2,21,26)/t9-,12-/m0/s1 |
| Cas号 | 2060571-02-8 |
| 相关CAS号 |
订购信息
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