GDC-0810 (Brilanestrant, ARN-810, RG6046) is a selective estrogen receptor degrader (SERD) that is designed to bind to the estrogen receptor to limit its function. In addition, when SERDs bind to the estrogen receptor, they may be able to change the shape of the receptor in such a way that the cell eliminates it by degradation.
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名称 | GDC-0810 ( Brilanestrant , ARN-810 ) |
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Iupac 化学名称 | (E)-3-(4-((E)-2-(2-chloro-4-fluorophenyl)-1-(1H-indazol-5-yl)but-1-en-1-yl)phenyl)acrylic acid |
同义词 | Brilanestrant ; GDC-0810 ; GDC 0810 ; GDC0810 ; ARN-810 ; ARN 810 ; ARN810 |
英文同义词 | Brilanestrant ; GDC-0810 ; GDC 0810 ; GDC0810 ; ARN-810 ; ARN 810 ; ARN810 |
分子式 | C26H20ClFN2O2 |
分子量 | 446.90 |
Smile | O=C(O)/C=C/C1=CC=C(/C(C2=CC3=C(NN=C3)C=C2)=C(C4=CC=C(F)C=C4Cl)/CC)C=C1 |
InChiKey | BURHGPHDEVGCEZ-KJGLQBJMSA-N |
InChi | InChI=1S/C26H20ClFN2O2/c1-2-21(22-10-9-20(28)14-23(22)27)26(18-8-11-24-19(13-18)15-29-30-24)17-6-3-16(4-7-17)5-12-25(31)32/h3-15H,2H2,1H3,(H,29,30)(H,31,32)/b12-5+,26-21+ |
Cas号 | 1365888-06-7 |
相关CAS号 | 1365888-06-7 |
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