GSK2256098, also known as GTPL7939, is a focal adhesion kinase-1 (FAK) inhibitor with potential antiangiogenic and antineoplastic activities. FAK inhibitor GSK2256098 inhibits FAK, which may prevent the integrin-mediated activation of several downstream signal transduction pathways, including ERK, JNK/MAPK and PI3K/Akt, thereby inhibiting tumor cell migration, proliferation and survival, and tumor angiogenesis. The tyrosine kinase FAK is normally activated by binding to integrins in the extracellular matrix (ECM) but may be upregulated and constitutively activated in various tumor cell types.
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化学信息
名称 | GSK-2256098 |
Iupac 化学名称 | GSK-2256098 |
同义词 | GSK2256098; GSK 2256098; GSK-2256098; GTPL7939; GTPL-7939; GTP L7939 |
英文同义词 | GSK2256098; GSK 2256098; GSK-2256098; GTPL7939; GTPL-7939; GTP L7939 |
分子式 | C20H23ClN6O2 |
分子量 | 414.894 |
InChiKey | |
InChi | |
Cas号 | 1224887-10-8 |
相关CAS号 | |
外观性状 | crystalline solid |
纯度 | 98% |
存储 | 3 years -20ºCpowder |
可溶性 | Soluble in DMSO |
处理方式 | |
运输条件 | Shipped under ambient temperature as non-hazardous chemical. |
海关编码 | |
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Mechanism | |
Cell study | |
Animal study | |
Clinical study | |