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GSK1059865

编号: 24131
Cas号: 1191044-58-2
纯度: 98% Min.

GSK1059865 is a potent orexin 1 receptor antagonist.

仅供研究使用。 我们不向患者出售。

化学信息

名称GSK1059865
Iupac 化学名称((2S,5S)-2-(((5-bromopyridin-2-yl)amino)methyl)-5-methylpiperidin-1-yl)(3-fluoro-2-methoxyphenyl)methanone
同义词GSK1059865; GSK 1059865; GSK-1059865
英文同义词GSK1059865; GSK 1059865; GSK-1059865
分子式C20H23BrFN3O2
分子量436.32
SmileO=C(N1[C@H](CNC2=NC=C(Br)C=C2)CC[C@H](C)C1)C3=CC=CC(F)=C3OC
InChiKeyTWCRHJLMMAYSTE-ZFWWWQNUSA-N
InChiInChI=1S/C20H23BrFN3O2/c1-13-6-8-15(11-24-18-9-7-14(21)10-23-18)25(12-13)20(26)16-4-3-5-17(22)19(16)27-2/h3-5,7,9-10,13,15H,6,8,11-12H2,1-2H3,(H,23,24)/t13-,15-/m0/s1
Cas号1191044-58-2
相关CAS号

订购信息

包装价格库存纯度备货期
大货询价询价询价
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外观性状类白色固体
纯度98% Min.
存储 0-4℃,可保存几天到几周;-20℃,可保存 几个月。
可溶性溶于DMSO等有机溶剂
处理方式
运输条件可以在室温下进行运输。
海关编码
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study

1: Lopez MF, Moorman DE, Aston-Jones G, Becker HC. The highly selective
orexin/hypocretin 1 receptor antagonist GSK1059865 potently reduces ethanol
drinking in ethanol dependent mice. Brain Res. 2016 Apr 1;1636:74-80. doi:
10.1016/j.brainres.2016.01.049. Epub 2016 Feb 4. PMID: 26851547; PMCID:
PMC4808605.

2: Merlo Pich E, Melotto S. Orexin 1 receptor antagonists in compulsive behavior
and anxiety: possible therapeutic use. Front Neurosci. 2014 Feb 13;8:26. doi:
10.3389/fnins.2014.00026. PMID: 24592206; PMCID: PMC3923148.

3: Gozzi A, Turrini G, Piccoli L, Massagrande M, Amantini D, Antolini M,
Martinelli P, Cesari N, Montanari D, Tessari M, Corsi M, Bifone A. Functional
magnetic resonance imaging reveals different neural substrates for the effects
of orexin-1 and orexin-2 receptor antagonists. PLoS One. 2011 Jan
28;6(1):e16406. doi: 10.1371/journal.pone.0016406. PMID: 21307957; PMCID:
PMC3030585.

4: Piccoli L, Micioni Di Bonaventura MV, Cifani C, Costantini VJ, Massagrande M,
Montanari D, Martinelli P, Antolini M, Ciccocioppo R, Massi M, Merlo-Pich E, Di
Fabio R, Corsi M. Role of orexin-1 receptor mechanisms on compulsive food
consumption in a model of binge eating in female rats. Neuropsychopharmacology.
2012 Aug;37(9):1999-2011. doi: 10.1038/npp.2012.48. Epub 2012 May 9. PMID:
22569505; PMCID: PMC3398727.

5: Gozzi A, Lepore S, Vicentini E, Merlo-Pich E, Bifone A. Differential effect
of orexin-1 and CRF-1 antagonism on stress circuits: a fMRI study in the rat
with the pharmacological stressor Yohimbine. Neuropsychopharmacology. 2013
Oct;38(11):2120-30. doi: 10.1038/npp.2013.109. Epub 2013 May 8. PMID: 23736277;
PMCID: PMC3773661.

化学结构

24131 - GSK1059865 | CAS 1191044-58-2

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